6p6e
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Mouse Importin alpha - PAC3 NLS peptide complex== | |
| - | + | <StructureSection load='6p6e' size='340' side='right'caption='[[6p6e]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6p6e]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P6E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ejl|1ejl]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6e OCA], [http://pdbe.org/6p6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p6e RCSB], [http://www.ebi.ac.uk/pdbsum/6p6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6e ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bernardes, N E]] | ||
| + | [[Category: Fontes, M R.M]] | ||
| + | [[Category: Fukuda, C A]] | ||
| + | [[Category: Oliveira, H C]] | ||
| + | [[Category: Silva, T D]] | ||
| + | [[Category: Importin alpha]] | ||
| + | [[Category: Nuclear import]] | ||
| + | [[Category: Transcription factor]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 15:33, 29 January 2020
Structure of Mouse Importin alpha - PAC3 NLS peptide complex
| |||||||||||
