This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ph6
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Ternary complex crystal structure of DNA polymerase Beta with 2nt-gap with dCTP bound downstream== | |
| - | + | <StructureSection load='6ph6' size='340' side='right'caption='[[6ph6]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ph6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PH6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ph6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ph6 OCA], [http://pdbe.org/6ph6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ph6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ph6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ph6 ProSAT]</span></td></tr> |
| - | [[Category: Wilson, S | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Batra, V K]] | ||
| + | [[Category: Wilson, S H]] | ||
| + | [[Category: Conformational change]] | ||
| + | [[Category: Dna polymerase beta]] | ||
| + | [[Category: Enzyme mechanism]] | ||
| + | [[Category: Misalignment mutagenesis]] | ||
| + | [[Category: Transcription-dna complex]] | ||
Revision as of 15:12, 11 December 2019
Ternary complex crystal structure of DNA polymerase Beta with 2nt-gap with dCTP bound downstream
| |||||||||||
