6rz9

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'''Unreleased structure'''
 
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The entry 6rz9 is ON HOLD until Paper Publication
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==Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372==
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<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [http://pdbe.org/6rz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [http://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.
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== Function ==
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[[http://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Besserer-Offroy, E]]
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[[Category: Borshchevskiy, V]]
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[[Category: Brouillette, R L]]
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[[Category: Cherezov, V]]
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[[Category: Ergasheva, M]]
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[[Category: Fujimoto, T]]
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[[Category: Gordeliy, V]]
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[[Category: Gusach, A]]
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[[Category: Han, G W]]
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[[Category: Ishchenko, A]]
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[[Category: Katritch, V]]
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[[Category: Kovalev, K]]
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[[Category: Longpre, J M]]
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[[Category: Luginina, A]]
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[[Category: Marin, E]]
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[[Category: Maruyama, T]]
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[[Category: Mishin, A]]
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[[Category: Popov, P]]
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[[Category: Romanovskaya, D]]
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[[Category: Sarret, P]]
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[[Category: Shevtsov, M]]
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[[Category: Stauch, B]]
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[[Category: Stepko, A]]
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[[Category: Asthma]]
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[[Category: Bril]]
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[[Category: Cyslt2]]
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[[Category: Cyslt2r]]
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[[Category: Cysltr2]]
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[[Category: Cysteinyl leukotriene]]
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[[Category: Cysteinyl leukotriene receptor 2]]
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[[Category: Gpcr]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]

Revision as of 15:22, 11 December 2019

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372

PDB ID 6rz9

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