6s6d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex== | |
| - | + | <StructureSection load='6s6d' size='340' side='right'caption='[[6s6d]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s6d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S6D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9JE:pentane-1,5-diol'>9JE</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s6d OCA], [http://pdbe.org/6s6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s6d RCSB], [http://www.ebi.ac.uk/pdbsum/6s6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s6d ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/RRAGA_HUMAN RRAGA_HUMAN]] Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.<ref>PMID:20381137</ref> <ref>PMID:25936802</ref> <ref>PMID:8995684</ref> <ref>PMID:9394008</ref> [[http://www.uniprot.org/uniprot/RRAGC_HUMAN RRAGC_HUMAN]] Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.<ref>PMID:20381137</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Anandapadamanaban, M]] | [[Category: Anandapadamanaban, M]] | ||
[[Category: Kaufman, J]] | [[Category: Kaufman, J]] | ||
| + | [[Category: Masson, G R]] | ||
| + | [[Category: Perisic, O]] | ||
| + | [[Category: Williams, R L]] | ||
| + | [[Category: Gtpase domain]] | ||
| + | [[Category: Mtorc1 activator]] | ||
| + | [[Category: Roadblock domain]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Small gtpase]] | ||
Revision as of 06:01, 16 October 2019
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
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