6sad
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164== | |
| - | + | <StructureSection load='6sad' size='340' side='right'caption='[[6sad]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sad]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SAD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-2 Caspase-2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.55 3.4.22.55] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sad OCA], [http://pdbe.org/6sad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sad RCSB], [http://www.ebi.ac.uk/pdbsum/6sad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sad ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/1433G_HUMAN 1433G_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:16511572</ref> [[http://www.uniprot.org/uniprot/CASP2_HUMAN CASP2_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caspase-2]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kalabova, D]] | ||
[[Category: Obsil, T]] | [[Category: Obsil, T]] | ||
[[Category: Obsilova, V]] | [[Category: Obsilova, V]] | ||
| - | [[Category: | + | [[Category: 14-3-3 protein]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 16:17, 22 January 2020
Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164
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