2qzl

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{{STRUCTURE_2qzl| PDB=2qzl | SCENE= }}
{{STRUCTURE_2qzl| PDB=2qzl | SCENE= }}
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'''Crystal Structure of human Beta Secretase complexed with IXS'''
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===Crystal Structure of human Beta Secretase complexed with IXS===
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==Overview==
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A series of beta-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors containing a psi(CH2NH) reduced amide bond were synthesized. Incorporation of this reduced amide isostere as a non-cleavable peptide surrogate afforded inhibitors possessing low nanomolar potencies in both an enzymatic and cell-based assay.
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(as it appears on PubMed at http://www.pubmed.gov), where 16690314 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16690314}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:41:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:52:46 2008''

Revision as of 12:52, 29 July 2008

Image:2qzl.png

Template:STRUCTURE 2qzl

Crystal Structure of human Beta Secretase complexed with IXS

Template:ABSTRACT PUBMED 16690314

About this Structure

2QZL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres., Coburn CA, Stachel SJ, Jones KG, Steele TG, Rush DM, DiMuzio J, Pietrak BL, Lai MT, Huang Q, Lineberger J, Jin L, Munshi S, Katharine Holloway M, Espeseth A, Simon A, Hazuda D, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2006 Jul 15;16(14):3635-8. Epub 2006 May 11. PMID:16690314

Page seeded by OCA on Tue Jul 29 15:52:46 2008

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