2rki

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'''Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI'''
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===Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI===
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==Overview==
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A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.
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(as it appears on PubMed at http://www.pubmed.gov), where 18083512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18083512}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:36:06 2008''

Revision as of 15:36, 27 July 2008

Image:2rki.png

Template:STRUCTURE 2rki

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI

Template:ABSTRACT PUBMED 18083512

About this Structure

2RKI is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis., Kirschberg TA, Balakrishnan M, Huang W, Hluhanich R, Kutty N, Liclican AC, McColl DJ, Squires NH, Lansdon EB, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. Epub 2007 Dec 5. PMID:18083512

Page seeded by OCA on Sun Jul 27 18:36:06 2008

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