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2j4s
From Proteopedia
(Difference between revisions)
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<StructureSection load='2j4s' size='340' side='right'caption='[[2j4s]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2j4s' size='340' side='right'caption='[[2j4s]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2j4s]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2j4s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4S FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bu7|1bu7]], [[1bvy|1bvy]], [[1fag|1fag]], [[1fah|1fah]], [[1jme|1jme]], [[1jpz|1jpz]], [[1p0v|1p0v]], [[1p0w|1p0w]], [[1p0x|1p0x]], [[1smi|1smi]], [[1smj|1smj]], [[1yqo|1yqo]], [[1yqp|1yqp]], [[2bmh|2bmh]], [[2hpd|2hpd]], [[2j1m|2j1m]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bu7|1bu7]], [[1bvy|1bvy]], [[1fag|1fag]], [[1fah|1fah]], [[1jme|1jme]], [[1jpz|1jpz]], [[1p0v|1p0v]], [[1p0w|1p0w]], [[1p0x|1p0x]], [[1smi|1smi]], [[1smj|1smj]], [[1yqo|1yqo]], [[1yqp|1yqp]], [[2bmh|2bmh]], [[2hpd|2hpd]], [[2j1m|2j1m]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4s OCA], [https://pdbe.org/2j4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4s RCSB], [https://www.ebi.ac.uk/pdbsum/2j4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4s ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:06, 12 May 2021
P450 BM3 heme domain in complex with DMSO
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