1l4t

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<StructureSection load='1l4t' size='340' side='right'caption='[[1l4t]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1l4t' size='340' side='right'caption='[[1l4t]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1l4t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L4T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1l4t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4T FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4t OCA], [http://pdbe.org/1l4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l4t RCSB], [http://www.ebi.ac.uk/pdbsum/1l4t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4t OCA], [https://pdbe.org/1l4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4t RCSB], [https://www.ebi.ac.uk/pdbsum/1l4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GASR_HUMAN GASR_HUMAN]] Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref> Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref>
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[[https://www.uniprot.org/uniprot/GASR_HUMAN GASR_HUMAN]] Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref> Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 05:52, 28 April 2021

SOLUTION NMR STRUCTURE OF THE CCK2E3

PDB ID 1l4t

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