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1z7s

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Revision as of 06:08, 28 April 2021

The crystal structure of coxsackievirus A21

Structural highlights

1z7s is a 4 chain structure with sequence from Cv-a21. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.,Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG Structure. 2005 Jul;13(7):1019-33. PMID:16004874^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG. The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Structure. 2005 Jul;13(7):1019-33. PMID:16004874 doi:10.1016/j.str.2005.04.011

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z7s"

@@ Line 3: / Line 3: @@
 <StructureSection load='1z7s' size='340' side='right'caption='[[1z7s]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1z7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cv-a21 Cv-a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z7S FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1z7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cv-a21 Cv-a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7S FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7s OCA], [http://pdbe.org/1z7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z7s RCSB], [http://www.ebi.ac.uk/pdbsum/1z7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7s ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7s OCA], [https://pdbe.org/1z7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7s RCSB], [https://www.ebi.ac.uk/pdbsum/1z7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7s ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

1z7s

From Proteopedia

Revision as of 06:08, 28 April 2021

The crystal structure of coxsackievirus A21

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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