6ps8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin.== | |
| - | + | <StructureSection load='6ps8' size='340' side='right'caption='[[6ps8]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ps8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PS8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ps8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ps8 OCA], [http://pdbe.org/6ps8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ps8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ps8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ps8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Batyuk, A]] | ||
| + | [[Category: Cherezov, C]] | ||
| + | [[Category: Gati, C]] | ||
| + | [[Category: Han, G W]] | ||
| + | [[Category: Ishchenko, A]] | ||
| + | [[Category: Iwata, S]] | ||
| + | [[Category: Joti, Y]] | ||
| + | [[Category: Li, C]] | ||
| + | [[Category: Liu, W]] | ||
| + | [[Category: Moraes, I]] | ||
| + | [[Category: Nakane, T]] | ||
| + | [[Category: Nango, E]] | ||
| + | [[Category: Shiriaeva, A]] | ||
| + | [[Category: Stauch, B]] | ||
| + | [[Category: Tanaka, R]] | ||
| + | [[Category: Tono, K]] | ||
| + | [[Category: Weierstall, U]] | ||
| + | [[Category: Zatsepin, N A]] | ||
| + | [[Category: 2-phenyl melatonin]] | ||
| + | [[Category: Agomelatine]] | ||
| + | [[Category: Complex-lcp method]] | ||
| + | [[Category: Drug design]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Lcp-sfx]] | ||
| + | [[Category: Ligand exchange]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mt1]] | ||
| + | [[Category: Sbdd]] | ||
| + | [[Category: Xfel]] | ||
Revision as of 11:09, 13 November 2019
XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin.
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Categories: Large Structures | Batyuk, A | Cherezov, C | Gati, C | Han, G W | Ishchenko, A | Iwata, S | Joti, Y | Li, C | Liu, W | Moraes, I | Nakane, T | Nango, E | Shiriaeva, A | Stauch, B | Tanaka, R | Tono, K | Weierstall, U | Zatsepin, N A | 2-phenyl melatonin | Agomelatine | Complex-lcp method | Drug design | Gpcr | Lcp-sfx | Ligand exchange | Membrane protein | Mt1 | Sbdd | Xfel
