6rlb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Structure of the dynein-2 complex; tail domain== |
| - | + | <StructureSection load='6rlb' size='340' side='right'caption='[[6rlb]], [[Resolution|resolution]] 4.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6rlb]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RLB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rlb OCA], [http://pdbe.org/6rlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rlb RCSB], [http://www.ebi.ac.uk/pdbsum/6rlb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rlb ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DC2L1_HUMAN DC2L1_HUMAN]] Jeune syndrome;Ellis Van Creveld syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/WDR34_HUMAN WDR34_HUMAN]] Short rib-polydactyly syndrome, Verma-Naumoff type;Jeune syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/WDR60_HUMAN WDR60_HUMAN]] Short rib-polydactyly syndrome, Verma-Naumoff type;Jeune syndrome. The disease is caused by mutations affecting the gene represented in this entry. Fibroblasts from affected individuals exhibit a defect in ciliogenesis and aberrant accumulation of the GLI2 transcription factor at the centrosome or basal body in the absence of an obvious axoneme. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DYL1_HUMAN DYL1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> [[http://www.uniprot.org/uniprot/DC2L1_HUMAN DC2L1_HUMAN]] Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length.<ref>PMID:26077881</ref> <ref>PMID:26130459</ref> [[http://www.uniprot.org/uniprot/WDR34_HUMAN WDR34_HUMAN]] Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.<ref>PMID:19521662</ref> <ref>PMID:24183449</ref> [[http://www.uniprot.org/uniprot/WDR60_HUMAN WDR60_HUMAN]] May play a role in ciliogenesis.<ref>PMID:23910462</ref> [[http://www.uniprot.org/uniprot/DLRB1_HUMAN DLRB1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carter, A P]] | ||
| + | [[Category: Mladenov, M]] | ||
| + | [[Category: Mukhopadhyay, A G]] | ||
| + | [[Category: Roberts, A J]] | ||
| + | [[Category: Toropova, K]] | ||
| + | [[Category: Zalyte, R]] | ||
| + | [[Category: Cilia]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Dynein]] | ||
| + | [[Category: Intraflagellar transport]] | ||
| + | [[Category: Motor protein]] | ||
Revision as of 15:42, 28 August 2019
Structure of the dynein-2 complex; tail domain
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