2za5

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<StructureSection load='2za5' size='340' side='right'caption='[[2za5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2za5' size='340' side='right'caption='[[2za5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2za5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZA5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2za5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZA5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2FF:(5-(AMINOMETHYL)-2H-SPIRO[BENZOFURAN-3,4-PIPERIDINE]-1-YL)(5-(PHENYLETHYNYL)FURAN-2-YL)METHANONE'>2FF</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FF:(5-(AMINOMETHYL)-2H-SPIRO[BENZOFURAN-3,4-PIPERIDINE]-1-YL)(5-(PHENYLETHYNYL)FURAN-2-YL)METHANONE'>2FF</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2za5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2za5 OCA], [http://pdbe.org/2za5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2za5 RCSB], [http://www.ebi.ac.uk/pdbsum/2za5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2za5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2za5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2za5 OCA], [https://pdbe.org/2za5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2za5 RCSB], [https://www.ebi.ac.uk/pdbsum/2za5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2za5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
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[[https://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 10:48, 8 December 2021

Crystal Structure of human tryptase with potent non-peptide inhibitor

PDB ID 2za5

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