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2ovu

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<StructureSection load='2ovu' size='340' side='right'caption='[[2ovu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2ovu' size='340' side='right'caption='[[2ovu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ovu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cangl Cangl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OVU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ovu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ow4|2ow4]], [[2p2k|2p2k]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ow4|2ow4]], [[2p2k|2p2k]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ovu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovu OCA], [http://pdbe.org/2ovu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ovu RCSB], [http://www.ebi.ac.uk/pdbsum/2ovu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovu OCA], [https://pdbe.org/2ovu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovu RCSB], [https://www.ebi.ac.uk/pdbsum/2ovu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
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[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cangl]]
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[[Category: Canavalia gladiata]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Azevedo, W F.de]]
[[Category: Azevedo, W F.de]]
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[[Category: Rocha, B A.M da]]
[[Category: Rocha, B A.M da]]
[[Category: Souza, E P.de]]
[[Category: Souza, E P.de]]
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[[Category: Canavalia gladiata]]
 
[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Man1-2mano-me]]
[[Category: Man1-2mano-me]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]

Revision as of 13:07, 9 June 2021

Crystal structure of a lectin from Canavalia gladiata (CGL) in complex with man1-2man-OMe

PDB ID 2ovu

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OCA

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