Hormone

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	===Chorionic Gonadotropin===		===Chorionic Gonadotropin===
-	[[1hrp]] - Chorionic Gonadotropin – human<br />	+	[[1hrp]], [[1hcn]] - hCG – human<br />
-	[[1hcn]] - Chorionic Gonadotropin – human<br />	+	[[1hd4]] - α-subunit of hCG <br />
-	[[1hd4]] - Alpha-subunit of Chorionic Gonadotropin – human<br />	+	[[1e9j]], [[1dz7]] - α-subunit of hCG - NMR<br />
		+	[[1qfw]] - hCG + antibody<br />
	===Estrogen-related Receptor===		===Estrogen-related Receptor===
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	[[Insulin]]		[[Insulin]]
-	===Progesterone receptor===	+	===Progesterone ===
-	[[3hq5]], [[3g8o]] - hProgR steroid-binding domain – human<br />
	[[1a28]] - hProgR steroid-binding domain + progesterone<br />		[[1a28]] - hProgR steroid-binding domain + progesterone<br />
-	[[4oar]], [[2ovm]], [[2ovh]] - hProgR steroid-binding domain + SMRT peptide<br />
-	[[4apu]], [[4a2j]], [[1zuc]] - hProgR steroid-binding domain + agonist<br />
-	[[3kba]] - hProgR steroid-binding domain + partial agonist<br />
-	[[3zrb]], [[3zra]], [[3zr7]] - hProgR steroid-binding domain + modulator<br />
-	[[3d90]] - hProgR steroid-binding domain + levonorgestrel<br />
-	[[2w8y]] - hProgR steroid-binding domain + RU486<br />
-	[[1sr7]] - hProgR steroid-binding domain + mometasone furoate<br />
-	[[1sqn]] - hProgR steroid-binding domain + northindrone<br />
-	[[1e3k]] - hProgR steroid-binding domain + metribolone<br />
-	[[2c7a]] - hProgR DNA-binding domain + DNA<br />
	===Thyroid-Stimulating hormone===		===Thyroid-Stimulating hormone===

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Revision as of 10:03, 1 August 2019

In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and their Receptors

Articles in Proteopedia concerning Hormone include:

To view automatically seeded indices concerning Hormone, see:

• Hormone
• Hormone Receptor
• Steroid receptor
• Steroid hormone receptor

Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules

Adrenaline

Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.

Angiotensinogen

2wxw, 2wxx, 2wxy, 2wxz, 2wy0, 2wy1, 2x0b - Angiotensinogen – human, rat, mouse

Chorionic Gonadotropin

1hrp, 1hcn - hCG – human
1hd4 - α-subunit of hCG
1e9j, 1dz7 - α-subunit of hCG - NMR
1qfw - hCG + antibody

Estrogen-related Receptor

Estrogen-related receptor

Androgen Receptor

Nuclear Androgen Receptor

Farnesoid X Receptor

3olf, 3omk, 3omm, 3oof, 3ook, 3okh, 3oki - Farnesoid X Receptor – human

Follicle-Stimulating Hormone

Follicle-stimulating hormone

PACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular

Glucocorticoid

Glucocorticoid receptor

Glucose-dependent Insulinotropic Polypeptide

Glucose-dependent Insulinotropic Polypeptide Receptor

Growth Hormone

Human growth hormone is featured here.

Insulin

Insulin

Progesterone

1a28 - hProgR steroid-binding domain + progesterone

Thyroid-Stimulating hormone

3g04 - TSH receptor in complex with a thyroid-stimulating autoantibody – human
2xwt - TSH receptor in complex with a thyroid-inactivating autoantibody – human

Thyroid hormone

2nll - DNA-Binding domain in complex with an inverted repeat class of thyroid response element– rat
1xzx

Thyroxine

2xn3, 2xn5, 2xn6, 2xn7 - Thyroxine-binding Globulin – human

domain of the human splice variant hPAC1-RS determined by NMR - human

ADD 3dzu

See Also

• Cancer
• Membrane proteins
• G protein-coupled receptors
• Nobel Prizes for 3D Molecular Structure
• Highest impact structures of all time

External Resources

• Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
• GRIS: Glycoprotein-hormone Receptors Information System
• The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors
• The feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB Molecule of the Month.
• NeuroPedia, a neuropeptide database and spectral library