Phosphoenolpyruvate carboxykinase

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*<scene name='54/540171/Cv/10'>Mn coordination site</scene>.
*<scene name='54/540171/Cv/10'>Mn coordination site</scene>.
*<scene name='54/540171/Cv/11'>Na coordination site</scene>.
*<scene name='54/540171/Cv/11'>Na coordination site</scene>.
 +
== 3D Structures of PEPCK ==
 +
[[Phosphoenolpyruvate carboxykinase 3D structures]]
</StructureSection>
</StructureSection>
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**[[1oen]], [[1fiy]] – EcPEPCK - ''Escherichia coli''<br />
**[[1oen]], [[1fiy]] – EcPEPCK - ''Escherichia coli''<br />
-
**[[6crt]] – EcPEPCK (mutant) + ATP + Mn<br />
+
**[[6at4]] – EcPEPCK + ATP + Mn<br />
 +
**[[6crt]], [[6asi]], [[6asm]], [[6asn]], [[6at2]], [[6at3]] – EcPEPCK (mutant) + ATP + Mn<br />
**[[6cu4]] – EcPEPCK (mutant) + pyruvate + Ca<br />
**[[6cu4]] – EcPEPCK (mutant) + pyruvate + Ca<br />
**[[1ayl]] – EcPEPCK + ATP + oxalate + Mg<br />
**[[1ayl]] – EcPEPCK + ATP + oxalate + Mg<br />
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**[[2qf1]] – rPEPCK + oxaloacetate + Mn<br />
**[[2qf1]] – rPEPCK + oxaloacetate + Mn<br />
**[[2rk7]], [[4ywb]] – rPEPCK + oxalate + Mn<br />
**[[2rk7]], [[4ywb]] – rPEPCK + oxalate + Mn<br />
 +
**[[6p5o]] – rPEPCK + picolinic acid derivative + Mn<br />
**[[2rk8]], [[2rka]], [[2rkd]], [[2rke]], [[4yw8]], [[4ywd]] – rPEPCK + inhibitor + Mn<br />
**[[2rk8]], [[2rka]], [[2rkd]], [[2rke]], [[4yw8]], [[4ywd]] – rPEPCK + inhibitor + Mn<br />
**[[4wiu]] – MtPEPCK + oxalate + Mn – ''Mycobacterium tuberculosis''<br />
**[[4wiu]] – MtPEPCK + oxalate + Mn – ''Mycobacterium tuberculosis''<br />

Revision as of 10:57, 17 November 2019

GTP-driven E. coli PEPCK complex with PEP, ethanediol, Na+ (purple) and Mn+2 ions (PDB entry 1khf)

Drag the structure with the mouse to rotate

3D Structures of PEPCK

Updated on 17-November-2019

References

  1. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem. 1997;66:581-611. PMID:9242918 doi:http://dx.doi.org/10.1146/annurev.biochem.66.1.581
  2. Dunten P, Belunis C, Crowther R, Hollfelder K, Kammlott U, Levin W, Michel H, Ramsey GB, Swain A, Weber D, Wertheimer SJ. Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J Mol Biol. 2002 Feb 15;316(2):257-64. PMID:11851336 doi:http://dx.doi.org/10.1006/jmbi.2001.5364

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