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6sc8

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'''Unreleased structure'''
 
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The entry 6sc8 is ON HOLD until Jul 23 2021
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==dAb3/HOIP-RBR-Ligand4==
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<StructureSection load='6sc8' size='340' side='right'caption='[[6sc8]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6sc8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SC8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6E:[2-(methylamino)-2-oxidanylidene-ethyl]+(~{E})-4-[(2-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-quinolin-3-yl)carbonylamino]but-2-enoate'>L6E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RBR-type_E3_ubiquitin_transferase RBR-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.31 2.3.2.31] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sc8 OCA], [http://pdbe.org/6sc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sc8 RCSB], [http://www.ebi.ac.uk/pdbsum/6sc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sc8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: RBR-type E3 ubiquitin transferase]]
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[[Category: House, D]]
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[[Category: Johansson, H]]
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[[Category: Rittinger, K]]
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[[Category: Tsai, Y C.I]]
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[[Category: Hoip]]
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[[Category: Human single domain antibody]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Rbr]]

Revision as of 06:58, 27 November 2019

dAb3/HOIP-RBR-Ligand4

PDB ID 6sc8

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