6sef
From Proteopedia
(Difference between revisions)
m (Protected "6sef" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Class2C : CENP-A nucleosome in complex with CENP-C central region== | |
| - | + | <StructureSection load='6sef' size='340' side='right'caption='[[6sef]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sef]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SEF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sef OCA], [http://pdbe.org/6sef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sef RCSB], [http://www.ebi.ac.uk/pdbsum/6sef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sef ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> [[http://www.uniprot.org/uniprot/CENPC_HUMAN CENPC_HUMAN]] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.<ref>PMID:19482874</ref> <ref>PMID:21529714</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ali-Ahmad, A]] | ||
| + | [[Category: Bilokapic, S]] | ||
| + | [[Category: Halic, M]] | ||
| + | [[Category: Schafer, I B]] | ||
| + | [[Category: Sekulic, N]] | ||
| + | [[Category: Cenp-a]] | ||
| + | [[Category: Centromere]] | ||
| + | [[Category: Centromeric chromatin]] | ||
| + | [[Category: Nuclear protein]] | ||
| + | [[Category: Nucleosome]] | ||
Revision as of 16:50, 14 August 2019
Class2C : CENP-A nucleosome in complex with CENP-C central region
| |||||||||||
