This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6jze

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:35, 7 April 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6jze' size='340' side='right'caption='[[6jze]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='6jze' size='340' side='right'caption='[[6jze]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6jze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JZE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6jze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JZE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jze OCA], [https://pdbe.org/6jze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jze RCSB], [https://www.ebi.ac.uk/pdbsum/6jze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jze ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jze OCA], [http://pdbe.org/6jze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jze RCSB], [http://www.ebi.ac.uk/pdbsum/6jze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jze ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE]] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref> [[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
+
[https://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
</div>
</div>
<div class="pdbe-citations 6jze" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6jze" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Tubulinyl-Tyr carboxypeptidase]]
+
[[Category: Mus musculus]]
-
[[Category: Chen, Z]]
+
[[Category: Chen Z]]
-
[[Category: Ling, Y]]
+
[[Category: Ling Y]]
-
[[Category: Zeyuan, G]]
+
[[Category: Zeyuan G]]
-
[[Category: Zhu, L]]
+
[[Category: Zhu L]]
-
[[Category: Cytosolic protein]]
+
-
[[Category: Svbp]]
+
-
[[Category: Tubulin detyrosination]]
+
-
[[Category: Vash2]]
+

Current revision

Crystal structure of VASH2-SVBP complex with the magic triangle I3C

PDB ID 6jze

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jze"
Personal tools