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Proliferating Cell Nuclear Antigen

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== Structural highlights ==
== Structural highlights ==
p15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the <scene name='43/439961/Cv/5'>peptide passes through the PCNA ring</scene> and has <scene name='43/439961/Cv/6'>numerous interactions with it</scene><ref>PMID:25762514</ref>.
p15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the <scene name='43/439961/Cv/5'>peptide passes through the PCNA ring</scene> and has <scene name='43/439961/Cv/6'>numerous interactions with it</scene><ref>PMID:25762514</ref>.
 +
 +
== 3D Structures of Proliferating Cell Nuclear Antigen ==
 +
[[Proliferating cell nuclear antigen 3D structures]]
 +
</StructureSection>
</StructureSection>
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*Unliganded PCNA
*Unliganded PCNA
-
**[[1rwz]] – AfPCNA - ''Archaeglobus fulgidus''<br />
+
**[[1vym]], [[1w60]], [[3vkx]] – hPCNA - human<br />
-
**[[3lx1]] - TkPCNA1 - ''Thermococcus kodakarensis''<br />
+
**[[5mom]], [[5e0t]] – hPCNA (mutant)<br />
-
**[[5a6d]] - PCNA - ''Thermococcus gammatolerans''<br />
+
-
**[[3lx2]] - TkPCNA2<br />
+
**[[3lox]], [[1plq]], [[1plr]], [[4yhr]], [[5t9d]] – yPCNA - yeast<br />
**[[3lox]], [[1plq]], [[1plr]], [[4yhr]], [[5t9d]] – yPCNA - yeast<br />
-
**[[3f1x]], [[3gpm]], [[3gpn]], [[3f1w]], [[4l60]], [[4l6p]], [[6cx2]], [[6cx3]], [[6cx4]], [[5v7m]], [[5v7l]], [[5v7k]] - yPCNA (mutant)<br />
+
**[[3f1x]], [[3gpm]], [[3gpn]], [[3f1w]], [[4l60]], [[4l6p]], [[6cx2]], [[6cx3]], [[6cx4]], [[5v7m]], [[5v7l]], [[5v7k]], [[6d0r]], [[6d0q]], [[6cx4]], [[6cx3]], [[6cx2]] - yPCNA (mutant)<br />
**[[3l0x]] - yPCNA N fragment + C fragment<br />
**[[3l0x]] - yPCNA N fragment + C fragment<br />
**[[3pge]] - yPCNA N fragment + SUMO-C fragment<br />
**[[3pge]] - yPCNA N fragment + SUMO-C fragment<br />
-
**[[1vym]], [[1w60]], [[3vkx]] – hPCNA - human<br />
 
-
**[[5mom]], [[5e0t]] – hPCNA (mutant)<br />
 
**[[5e0t]], [[5mom]] - hPCNA (mutant)<br />
**[[5e0t]], [[5mom]] - hPCNA (mutant)<br />
**[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br />
**[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br />
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**[[4cs5]] – PCNA – ''Litopenaeus vannamei''<br />
**[[4cs5]] – PCNA – ''Litopenaeus vannamei''<br />
**[[5cfk]], [[5b7o]], [[5h0t]], [[5hac]] - PCNA - ''Leishmania donovani''<br />
**[[5cfk]], [[5b7o]], [[5h0t]], [[5hac]] - PCNA - ''Leishmania donovani''<br />
 +
**[[1rwz]] – AfPCNA - ''Archaeglobus fulgidus''<br />
 +
**[[3lx1]] - TkPCNA1 - ''Thermococcus kodakarensis''<br />
 +
**[[5a6d]] - PCNA - ''Thermococcus gammatolerans''<br />
 +
**[[3lx2]] - TkPCNA2<br />
*PCNA + Dpo
*PCNA + Dpo
 +
**[[6hvo]] - hPCNA + hDpo δ<br />
**[[2zvk]] – hPCNA + hDpo ε<br />
**[[2zvk]] – hPCNA + hDpo ε<br />
**[[2zvl]] – hPCNA + hDpo κ<br />
**[[2zvl]] – hPCNA + hDpo κ<br />
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*PCNA complexes
*PCNA complexes
-
**[[1vyj]], [[1u76]], [[1u7b]], [[6cbi]], [[5yd8]], [[5yco]], [[5mlw]], [[5mlo]], [[5mav]], [[5iy4]], [[4ztd]], [[4rjf]] – hPCNA + peptide<br />
+
**[[1vyj]], [[1u76]], [[1u7b]], [[6cbi]], [[5yd8]], [[5yco]], [[5mlw]], [[5mlo]], [[5mav]], [[5iy4]], [[4ztd]], [[4rjf]], [[6fcn]] – hPCNA + peptide<br />
**[[5e0u]] - hPCNA (mutant) + peptide<br />
**[[5e0u]] - hPCNA (mutant) + peptide<br />
**[[4d2g]], [[6gws]] – hPCNA + p15 peptide<br />
**[[4d2g]], [[6gws]] – hPCNA + p15 peptide<br />
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**[[6eht]] – hPCNA + p15 peptide + DNA<br />
**[[6eht]] – hPCNA + p15 peptide + DNA<br />
**[[5e0v]] - hPCNA + Flap structure-specific endonuclease peptide<br />
**[[5e0v]] - hPCNA + Flap structure-specific endonuclease peptide<br />
 +
**[[6qcg]] – hPCNA + CDT1 peptide<br />
 +
**[[6qc0]] – hPCNA + CDT2 peptide<br />
 +
**[[6k3a]] – hPCNA + DNMT1 peptide<br />
 +
**[[6e49]] – hPCNA + PIF-1 peptide<br />
 +
**[[6cbi]] – hPCNA + peptide inhibitor<br />
 +
**[[6gws]] – hPCNA + PCNA-associated factor peptide<br />
 +
**[[6eht]] – hPCNA + PCNA-associated factor peptide + DNA<br />
**[[4ztd]] - hPCNA + ubiquitin ligase peptide<br />
**[[4ztd]] - hPCNA + ubiquitin ligase peptide<br />
**[[3wgw]] – hPCNA + inhibitor<br />
**[[3wgw]] – hPCNA + inhibitor<br />
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**[[5mav]] - hPCNA + PARG peptidee<br />
**[[5mav]] - hPCNA + PARG peptidee<br />
**[[6gis]] - hPCNA + DNA<br />
**[[6gis]] - hPCNA + DNA<br />
-
**[[3p83]] - AfPCNA + RNase H2<br />
 
-
**[[1rxm]] – AfPCNA + Flap exonuclease-1 peptide<br />
 
-
**[[1rxz]] - AfPCNA + Flap structure-specific endonuclease<br />
 
**[[3l0w]], [[3l10]] - yPCNA + monoubiquinated PCNA<br />
**[[3l0w]], [[3l10]] - yPCNA + monoubiquinated PCNA<br />
**[[1sxj]] – yPCNA + replication factor C<br />
**[[1sxj]] – yPCNA + replication factor C<br />
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**[[2izo]] - SsPCNA B + PCNA C + Flap structure-specific endonuclease<br />
**[[2izo]] - SsPCNA B + PCNA C + Flap structure-specific endonuclease<br />
**[[1isq]] - PfPCNA (mutant) + replication factor C large subunit<br />
**[[1isq]] - PfPCNA (mutant) + replication factor C large subunit<br />
-
**[[2zvw]], [[2zvv]] - PCNA + cyclin-dependent kinase inhibitor 1 - ''Arabidopsis thaliana''<br />
+
**[[2zvw]], [[2zvv]] - AtPCNA + cyclin-dependent kinase inhibitor 1 - ''Arabidopsis thaliana''<br />
 +
**[[6o09]] – AtPCNA + peptide<br />
**[[5da7]] - TkPCNA + protein inhibitor<br />
**[[5da7]] - TkPCNA + protein inhibitor<br />
 +
**[[3p83]] - AfPCNA + RNase H2<br />
 +
**[[1rxm]] – AfPCNA + Flap exonuclease-1 peptide<br />
 +
**[[1rxz]] - AfPCNA + Flap structure-specific endonuclease<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:37, 27 November 2019

Human proliferating cell nuclear antigen trimer (cyan, green, deeppink) complex with p15 peptide (yellow, magenta) (PDB entry 4d2g)

Drag the structure with the mouse to rotate

3D Structures of Proliferating Cell Nuclear Antigen

Updated on 27-November-2019

References

  1. ↑ Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
  2. ↑ Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908
  3. ↑ De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Carton D, Luque I, Diercks T, Bernado P, Montoya G, Blanco FJ. Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 2015 Mar 12;6:6439. doi: 10.1038/ncomms7439. PMID:25762514 doi:http://dx.doi.org/10.1038/ncomms7439

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