6ihj

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<StructureSection load='6ihj' size='340' side='right'caption='[[6ihj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6ihj' size='340' side='right'caption='[[6ihj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ihj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IHJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ihj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IHJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihj OCA], [http://pdbe.org/6ihj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ihj RCSB], [http://www.ebi.ac.uk/pdbsum/6ihj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihj ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sbr, nxf1, CG1664 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), Nxt1, CG12752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ihj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihj OCA], [http://pdbe.org/6ihj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ihj RCSB], [http://www.ebi.ac.uk/pdbsum/6ihj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NXF1_DROME NXF1_DROME]] Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm.<ref>PMID:11779805</ref> <ref>PMID:11780633</ref> <ref>PMID:11780634</ref> [[http://www.uniprot.org/uniprot/NXT1_DROME NXT1_DROME]] Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).[UniProtKB:Q9UKK6]<ref>PMID:14729961</ref>
[[http://www.uniprot.org/uniprot/NXF1_DROME NXF1_DROME]] Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm.<ref>PMID:11779805</ref> <ref>PMID:11780633</ref> <ref>PMID:11780634</ref> [[http://www.uniprot.org/uniprot/NXT1_DROME NXT1_DROME]] Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).[UniProtKB:Q9UKK6]<ref>PMID:14729961</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila, Panoramix enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs remain elusive. Here, we show that Panoramix functions together with a germline-specific paralogue of a nuclear export factor, dNxf2, and its cofactor dNxt1 (p15), to suppress transposon expression. The transposon RNA-binding protein dNxf2 is required for animal fertility and Panoramix-mediated silencing. Transient tethering of dNxf2 to nascent transcripts leads to their nuclear retention. The NTF2 domain of dNxf2 competes dNxf1 (TAP) off nucleoporins, a process required for proper RNA export. Thus, dNxf2 functions in a Panoramix-dNxf2-dependent TAP/p15 silencing (Pandas) complex that counteracts the canonical RNA exporting machinery and restricts transposons to the nuclear peripheries. Our findings may have broader implications for understanding how RNA metabolism modulates heterochromatin formation.
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A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.,Zhao K, Cheng S, Miao N, Xu P, Lu X, Zhang Y, Wang M, Ouyang X, Yuan X, Liu W, Lu X, Zhou P, Gu J, Zhang Y, Qiu D, Jin Z, Su C, Peng C, Wang JH, Dong MQ, Wan Y, Ma J, Cheng H, Huang Y, Yu Y Nat Cell Biol. 2019 Oct;21(10):1261-1272. doi: 10.1038/s41556-019-0396-0. Epub, 2019 Sep 30. PMID:31570835<ref>PMID:31570835</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ihj" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Huang, Y]]
[[Category: Huang, Y]]

Revision as of 10:18, 26 February 2020

Crystal structure of Drosophila Nxf1 NTF2 domain in complex with Nxt1/p15

PDB ID 6ihj

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