Protein kinase C
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/468129/Cv/6'>Phosphatidylinositol binds to PKC-α C2 domain groove</scene> near the <scene name='46/468129/Cv/7'>Ca+2 binding pocket</scene><ref>PMID:19346474</ref>. Water molecules are shown as red spheres. | <scene name='46/468129/Cv/6'>Phosphatidylinositol binds to PKC-α C2 domain groove</scene> near the <scene name='46/468129/Cv/7'>Ca+2 binding pocket</scene><ref>PMID:19346474</ref>. Water molecules are shown as red spheres. | ||
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| + | ==3D structures of protein kinase C== | ||
| + | [[Protein kinase C 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of protein kinase C== | ==3D structures of protein kinase C== | ||
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*PKC-α | *PKC-α | ||
| + | **[[2eli]] – hCPKC-α C1 domain – human – NMR<br /> | ||
| + | **[[4dnl]] - hCPKC-α C2 domain<br /> | ||
| + | **[[3iw4]], [[4ra4]] - hCPKC-α kinase domain + inhibitor<br /> | ||
**[[1dsy]], [[3rdj]], [[3twy]], [[2nce]] – rCPKC-α C2 domain – rat | **[[1dsy]], [[3rdj]], [[3twy]], [[2nce]] – rCPKC-α C2 domain – rat | ||
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**[[3gpe]] - rCPKC-α C2 domain + Ca + PTDINS | **[[3gpe]] - rCPKC-α C2 domain + Ca + PTDINS | ||
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| - | **[[2eli]] – hCPKC-α C1 domain – human – NMR<br /> | ||
| - | **[[4dnl]] - hCPKC-α C2 domain<br /> | ||
| - | **[[3iw4]], [[4ra4]] - hCPKC-α kinase domain + inhibitor | ||
*PKC-β | *PKC-β | ||
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**[[1tbn]], [[1tbo]] - rCPKC-γ C2 domain – NMR<br /> | **[[1tbn]], [[1tbo]] - rCPKC-γ C2 domain – NMR<br /> | ||
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*'''Novel PKC''' | *'''Novel PKC''' | ||
*PKC-δ | *PKC-δ | ||
| + | **[[1yrk]] – hNPKC-δ C2 domain + peptide | ||
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| + | **[[2yuu]] - hNPKC-δ C1 domain - NMR | ||
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| + | **[[2coa]] - hNPKC-δ PH domain – NMR<br /> | ||
**[[1ptq]] – mNPKC-δ C2 domain – mouse<br /> | **[[1ptq]] – mNPKC-δ C2 domain – mouse<br /> | ||
**[[3uej]] - mNPKC-δ C1B domain<br /> | **[[3uej]] - mNPKC-δ C1B domain<br /> | ||
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**[[1bdy]] - rNPKC-δ C2 domain | **[[1bdy]] - rNPKC-δ C2 domain | ||
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| - | **[[1yrk]] – hNPKC-δ C2 domain + peptide | ||
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| - | **[[2yuu]] - hNPKC-δ C1 domain - NMR | ||
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| - | **[[2coa]] - hNPKC-δ PH domain – NMR | ||
*PKC-ε | *PKC-ε | ||
Revision as of 11:34, 28 November 2019
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3D structures of protein kinase C
Updated on 28-November-2019
References
- ↑ Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. 2001 Jun;44(6):659-73. PMID:11440359 doi:http://dx.doi.org/10.1007/s001250051675
- ↑ Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun;47(6):859-66. PMID:9604860
- ↑ Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett. 2006 Apr 8;235(1):1-10. PMID:15907369 doi:http://dx.doi.org/10.1016/j.canlet.2005.03.033
- ↑ Guerrero-Valero M, Ferrer-Orta C, Querol-Audi J, Marin-Vicente C, Fita I, Gomez-Fernandez JC, Verdaguer N, Corbalan-Garcia S. Structural and mechanistic insights into the association of PKC{alpha}-C2 domain to PtdIns(4,5)P2. Proc Natl Acad Sci U S A. 2009 Apr 3. PMID:19346474
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