Retinol-binding protein
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='48/488393/Cv/7'>Retinol binds to cellular RBP II inside its internal cavity</scene><ref>PMID:18076076</ref>. <scene name='48/488393/Cv/8'>Active site</scene>. Water molecules are shown as red spheres. | <scene name='48/488393/Cv/7'>Retinol binds to cellular RBP II inside its internal cavity</scene><ref>PMID:18076076</ref>. <scene name='48/488393/Cv/8'>Active site</scene>. Water molecules are shown as red spheres. | ||
| + | ==3D structures of retinol-binding protein== | ||
| + | [[Retinol-binding protein 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
==3D structures of retinol-binding protein== | ==3D structures of retinol-binding protein== | ||
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**[[1rbp]], [[1jyd]], [[1brp]], [[1brq]] - hRBP – human<br /> | **[[1rbp]], [[1jyd]], [[1brp]], [[1brq]] - hRBP – human<br /> | ||
**[[1jyj]] - hRBP (mutant)<br /> | **[[1jyj]] - hRBP (mutant)<br /> | ||
| + | **[[5nty]], [[5nu2]], [[5nu6]], [[5nu7]] - hRBP IV<br /> | ||
**[[1aqb]] - RBP – pig<br /> | **[[1aqb]] - RBP – pig<br /> | ||
**[[1hbq]] – bRBP – bovine<br /> | **[[1hbq]] – bRBP – bovine<br /> | ||
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**[[2wq9]] - hRBP IV + oleate<br /> | **[[2wq9]] - hRBP IV + oleate<br /> | ||
**[[2wr6]] - hRBP IV + linoleate<br /> | **[[2wr6]] - hRBP IV + linoleate<br /> | ||
| + | **[[5nu8]], [[5nu9]] - hRBP IV + palmitate<br /> | ||
| + | **[[5nua]], [[5nub]] - hRBP IV + laurate<br /> | ||
**[[2wqa]] - hRBP IV + transthyretin + oleate<br /> | **[[2wqa]] - hRBP IV + transthyretin + oleate<br /> | ||
**[[4o9s]], [[4psq]] - hRBP IV + non-retinoid<br /> | **[[4o9s]], [[4psq]] - hRBP IV + non-retinoid<br /> | ||
| - | + | **[[1kt3]], [[1kt4]], [[1kt5]], [[1kt6]], [[1kt7]], [[1hbp]] - bRBP + retinol <br /> | |
| - | + | ||
| - | **[[1kt3]], [[1kt4]], [[1kt5]], [[1kt6]], [[1kt7]], [[1hbp]] - | + | |
**[[1erb]], [[1fel]], [[1fem]], [[1fen]] - bRBP + retinol derivative<br /> | **[[1erb]], [[1fel]], [[1fem]], [[1fen]] - bRBP + retinol derivative<br /> | ||
**[[1qab]] - rRBP + transthyretin<br /> | **[[1qab]] - rRBP + transthyretin<br /> | ||
| + | **[[1iiu]] - RBP + retinol – chicken<br /> | ||
| + | **[[1rlb]] - cRBP + transthyretin<br /> | ||
*'''Cellular RBP (CRBP)''' | *'''Cellular RBP (CRBP)''' | ||
| - | **[[1jbh]], [[1kgl]], [[1mx7]] - rRBP I – rat - NMR<BR /> | ||
**[[5h9a]], [[5ljb]], [[5ljc]], [[5ljg]], [[5ljk]] - hRBP I<br /> | **[[5h9a]], [[5ljb]], [[5ljc]], [[5ljg]], [[5ljk]] - hRBP I<br /> | ||
**[[5ljd]], [[5lje]], [[5ljh]] - hRBP I (mutant)<br /> | **[[5ljd]], [[5lje]], [[5ljh]] - hRBP I (mutant)<br /> | ||
| - | **[[ | + | **[[2rcq]], [[4zh9]], [[6mcv]] - hRBP II<br /> |
| - | + | **[[4zgu]], [[4zh6]], [[4zr2]], [[4zcb]], [[5dg4]], [[5dpq]], [[6e7m]], [[6mcu]], [[6mkv]], [[6mlb]], [[6on5]], [[6on7]], [[6on8]], [[6e6l]], [[6e50]], [[6e51]], [[6e5e]], [[6e5q]], [[6e5r]], [[6e5s]] - hRBP II (mutant)<br /> | |
| - | + | ||
| - | **[[4zgu]], [[4zh6]], [[4zr2]], [[4zcb]], [[5dg4]], [[5dpq]] - hRBP II (mutant)<br /> | + | |
**[[1ggl]] - hRBP III <br /> | **[[1ggl]] - hRBP III <br /> | ||
**[[1lpj]], [[6at8]] - hRBP IV<br /> | **[[1lpj]], [[6at8]] - hRBP IV<br /> | ||
| + | **[[1jbh]], [[1kgl]], [[1mx7]] - rRBP I – rat - NMR<BR /> | ||
| + | **[[1b4m]] - rRBP II – NMR<BR /> | ||
| + | **[[1opa]] – rRBP II<br /> | ||
**[[1kqx]] – ZeRBP – zebrafish<br /> | **[[1kqx]] – ZeRBP – zebrafish<br /> | ||
**[[4uet]] - NaRBP – Necator americanus - NMR<br /> | **[[4uet]] - NaRBP – Necator americanus - NMR<br /> | ||
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*Cellular RBP complex | *Cellular RBP complex | ||
| - | **[[1mx8]] - rRBP I + retinol – NMR<BR /> | ||
**[[5h8t]], [[5hbs]] - hRBP I + retinol<br /> | **[[5h8t]], [[5hbs]] - hRBP I + retinol<br /> | ||
**[[5ha1]] - hRBP I + retinol derivative<br /> | **[[5ha1]] - hRBP I + retinol derivative<br /> | ||
| - | **[[ | + | **[[6e6m]], [[6e5l]], [[6e5t]] - hRBP I + cannabidiocrin derivative<br /> |
**[[2rct]], [[4qyn]], [[4qyp]], [[4qzt]], [[4qzu]] - hRBP II + retinol<br /> | **[[2rct]], [[4qyn]], [[4qyp]], [[4qzt]], [[4qzu]] - hRBP II + retinol<br /> | ||
| - | **[[4zj0]], [[4ruu]], [[4ede]], [[4eej]], [[4efg]], [[4exz]], [[4gkc]], [[5f6b]], [[5f7g]], [[5ffh]], [[5f58]], [[5faz]], [[5fen]] - hRBP II (mutant) + retinol<br /> | + | **[[4zj0]], [[4ruu]], [[4ede]], [[4eej]], [[4efg]], [[4exz]], [[4gkc]], [[5f6b]], [[5f7g]], [[5ffh]], [[5f58]], [[5faz]], [[5fen]], [[5u6g]] - hRBP II (mutant) + retinol<br /> |
| - | **[[ | + | **[[6bth]] - hRBP II (mutant) + 2-AG<br /> |
| + | **[[6bti]] - hRBP II (mutant) + AEA<br /> | ||
| + | **[[6c7z]] - hRBP II (mutant) + quinolin derivative<br /> | ||
| + | **[[6e5w]] - hRBP III + cannabidiocrin derivative<br /> | ||
**[[1crb]], [[1opb]] - rRBP + retinol<br /> | **[[1crb]], [[1opb]] - rRBP + retinol<br /> | ||
| + | **[[1mx8]] - rRBP I + retinol – NMR<BR /> | ||
| + | **[[1eii]] - rRBP II + retinol – NMR<BR /> | ||
| + | **[[1kqw]] - ZeRBP + retinol<br /> | ||
**[[4xcp]] - NaRBP + palmitate<br /> | **[[4xcp]] - NaRBP + palmitate<br /> | ||
Revision as of 08:15, 15 December 2019
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3D structures of retinol-binding protein
Updated on 15-December-2019
References
- ↑ Goodman DS. Plasma retinol-binding protein. Ann N Y Acad Sci. 1980;348:378-90. PMID:6994566
- ↑ Ong DE. Cellular retinoid-binding proteins. Arch Dermatol. 1987 Dec;123(12):1693-1695a. PMID:2825608
- ↑ Filteau SM, Willumsen JF, Sullivan K, Simmank K, Gamble M. Use of the retinol-binding protein: transthyretin ratio for assessment of vitamin A status during the acute-phase response. Br J Nutr. 2000 May;83(5):513-20. PMID:10953676
- ↑ Cabre A, Lazaro I, Girona J, Manzanares J, Marimon F, Plana N, Heras M, Masana L. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes. J Intern Med. 2007 Oct;262(4):496-503. PMID:17875187 doi:http://dx.doi.org/10.1111/j.1365-2796.2007.01849.x
- ↑ Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL. Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. Proteins. 2008 Mar;70(4):1626-30. PMID:18076076 doi:http://dx.doi.org/10.1002/prot.21848
