Hydroxysteroid dehydrogenase

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* '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice<ref>PMID:17122075</ref>.<br />
* '''20-α HSD''' is involved in the control of progesterone level in pregnancy of mice<ref>PMID:17122075</ref>.<br />
* '''11-β HSD''' converts 11-keto products like cortisone to cortisol<ref>PMID:15466942</ref>.<br />
* '''11-β HSD''' converts 11-keto products like cortisone to cortisol<ref>PMID:15466942</ref>.<br />
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* '''17-β HSD''' is involved in the conversion of androstenedione to testosterone<ref>PMID:9029730</ref>.<br />
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* '''17-β HSD''' is involved in the conversion of androstenedione to testosterone<ref>PMID:9029730</ref>. See [[Human Keto Acyl Reductase]].<br />
* '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17<ref>PMID:1309351</ref>.<br />
* '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17<ref>PMID:1309351</ref>.<br />
[[NAD]] and NADP are cofactors of HSD.
[[NAD]] and NADP are cofactors of HSD.

Current revision

Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP 1lwi

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References

  1. ↑ Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology. 2003 Jul;144(7):2922-32. PMID:12810547 doi:http://dx.doi.org/10.1210/en.2002-0032
  2. ↑ Haslewood ES, Haslewood GA. The specificity of a 7 alpha-hydroxy steroid dehydrogenase from Escherichia coli. Biochem J. 1976 Jul 1;157(1):207-10. PMID:786279
  3. ↑ Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y. Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. Endocrinology. 2007 Mar;148(3):976-88. Epub 2006 Nov 22. PMID:17122075 doi:http://dx.doi.org/10.1210/en.2006-1100
  4. ↑ Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev. 2004 Oct;25(5):831-66. PMID:15466942 doi:http://dx.doi.org/10.1210/er.2003-0031
  5. ↑ Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Belanger A. The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. Steroids. 1997 Jan;62(1):148-58. PMID:9029730
  6. ↑ de Launoit Y, Simard J, Durocher F, Labrie F. Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. Endocrinology. 1992 Jan;130(1):553-5. PMID:1309351 doi:http://dx.doi.org/10.1210/endo.130.1.1309351
  7. ↑ Boehmer AL, Brinkmann AO, Sandkuijl LA, Halley DJ, Niermeijer MF, Andersson S, de Jong FH, Kayserili H, de Vroede MA, Otten BJ, Rouwe CW, Mendonca BB, Rodrigues C, Bode HH, de Ruiter PE, Delemarre-van de Waal HA, Drop SL. 17Beta-hydroxysteroid dehydrogenase-3 deficiency: diagnosis, phenotypic variability, population genetics, and worldwide distribution of ancient and de novo mutations. J Clin Endocrinol Metab. 1999 Dec;84(12):4713-21. PMID:10599740 doi:http://dx.doi.org/10.1210/jcem.84.12.6174
  8. ↑ Moisan AM, Ricketts ML, Tardy V, Desrochers M, Mebarki F, Chaussain JL, Cabrol S, Raux-Demay MC, Forest MG, Sippell WG, Peter M, Morel Y, Simard J. New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. J Clin Endocrinol Metab. 1999 Dec;84(12):4410-25. PMID:10599696
  9. ↑ Stewart PM, Burra P, Shackleton CH, Sheppard MC, Elias E. 11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease. J Clin Endocrinol Metab. 1993 Mar;76(3):748-51. PMID:8445034 doi:http://dx.doi.org/10.1210/jcem.76.3.8445034
  10. ↑ Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry. 1996 Aug 20;35(33):10702-11. PMID:8718859 doi:10.1021/bi9604688

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