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2jxv

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{{STRUCTURE_2jxv| PDB=2jxv | SCENE= }}
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'''Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans'''
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===Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans===
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==Overview==
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Let-7 microRNA (miRNA) regulates heterochronic genes in developmental timing of the nematode Caenorhabditis elegans. Binding of miRNA to messenger RNA (mRNA) and structural features of the complex are crucial for gene silencing. We herein present the NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site (LCS 2) in the 3' untranslated region (3'-UTR) of the lin-41 mRNA. A structural study was performed by NMR spectroscopy using NOE restraints, torsion angle restraints and residual dipolar couplings. The 33-nt RNA construct folds into a stem-loop structure that features two stem regions which are separated by an asymmetric internal loop. One of the stems comprises a GU wobble base pair, which does not alter its overall A-form RNA conformation. The asymmetric internal loop adopts a single, well-defined structure in which three uracils form a base triple, while two adenines form a base pair. The 3D structure of the construct gives insight into the structural aspects of interactions between let-7 miRNA and lin-41 mRNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 18296482 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18296482}}
==About this Structure==
==About this Structure==
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2JXV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].
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2JXV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXV OCA].
==Reference==
==Reference==
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[[Category: Residual dipolar coupling]]
[[Category: Residual dipolar coupling]]
[[Category: Stem-loop]]
[[Category: Stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 12:49:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:23:37 2008''

Revision as of 18:23, 28 July 2008

Image:2jxv.png

Template:STRUCTURE 2jxv

Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans

Template:ABSTRACT PUBMED 18296482

About this Structure

2JXV is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans., Cevec M, Thibaudeau C, Plavec J, Nucleic Acids Res. 2008 Apr;36(7):2330-7. Epub 2008 Feb 22. PMID:18296482

Page seeded by OCA on Mon Jul 28 21:23:37 2008

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