6pvm
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius== | |
| - | + | <StructureSection load='6pvm' size='340' side='right'caption='[[6pvm]], [[Resolution|resolution]] 4.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PVM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [http://pdbe.org/6pvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [http://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: McGoldrick, L L]] | ||
| + | [[Category: Singh, A K]] | ||
| + | [[Category: Sobolevsky, A I]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Trp channel]] | ||
Revision as of 06:59, 23 October 2019
Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius
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