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1b98
From Proteopedia
(Difference between revisions)
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<StructureSection load='1b98' size='340' side='right'caption='[[1b98]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='1b98' size='340' side='right'caption='[[1b98]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1b98]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1b98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. The August 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Neurotrophins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_8 10.2210/rcsb_pdb/mom_2005_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B98 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b98 OCA], [https://pdbe.org/1b98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b98 RCSB], [https://www.ebi.ac.uk/pdbsum/1b98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b98 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[https://omim.org/entry/613100 613100]]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Target-derived survival factor for peripheral sensory sympathetic neurons. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Neurotrophin|Neurotrophin]] | *[[Neurotrophin|Neurotrophin]] | ||
| + | *[[Neutrotrophin|Neutrotrophin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:05, 2 June 2021
NEUROTROPHIN 4 (HOMODIMER)
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