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3vw7

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<StructureSection load='3vw7' size='340' side='right'caption='[[3vw7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3vw7' size='340' side='right'caption='[[3vw7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VW7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VW7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=VPX:ETHYL+[(1R,3AR,4AR,6R,8AR,9S,9AS)-9-{(E)-2-[5-(3-FLUOROPHENYL)PYRIDIN-2-YL]ETHENYL}-1-METHYL-3-OXODODECAHYDRONAPHTHO[2,3-C]FURAN-6-YL]CARBAMATE'>VPX</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=VPX:ETHYL+[(1R,3AR,4AR,6R,8AR,9S,9AS)-9-{(E)-2-[5-(3-FLUOROPHENYL)PYRIDIN-2-YL]ETHENYL}-1-METHYL-3-OXODODECAHYDRONAPHTHO[2,3-C]FURAN-6-YL]CARBAMATE'>VPX</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vw7 OCA], [http://pdbe.org/3vw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vw7 RCSB], [http://www.ebi.ac.uk/pdbsum/3vw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vw7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vw7 OCA], [https://pdbe.org/3vw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vw7 RCSB], [https://www.ebi.ac.uk/pdbsum/3vw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vw7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAR1_HUMAN PAR1_HUMAN]] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.<ref>PMID:10079109</ref>
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[[https://www.uniprot.org/uniprot/PAR1_HUMAN PAR1_HUMAN]] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.<ref>PMID:10079109</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 19:07, 27 July 2022

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

PDB ID 3vw7

Drag the structure with the mouse to rotate

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