Synaptotagmin
From Proteopedia
(Difference between revisions)
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<StructureSection load='4npk' size='340' side='right' caption='Synaptostagmin-2 C2A and C2B domains complex with Ca+2 ions (green) (PDB code [[4npk]])' scene='80/802718/Cv/1'> | <StructureSection load='4npk' size='340' side='right' caption='Synaptostagmin-2 C2A and C2B domains complex with Ca+2 ions (green) (PDB code [[4npk]])' scene='80/802718/Cv/1'> | ||
| - | + | __TOC__ | |
== Function == | == Function == | ||
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*<scene name='80/802718/Cv/10'>3th Ca+2 binding site</scene>. | *<scene name='80/802718/Cv/10'>3th Ca+2 binding site</scene>. | ||
*<scene name='80/802718/Cv/11'>All Ca+2 binding sites</scene>. | *<scene name='80/802718/Cv/11'>All Ca+2 binding sites</scene>. | ||
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| + | ==3D structures of synaptotagmin== | ||
| + | [[Synaptotagmin 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[2r83]] – hSYT1 C2A+C2B domains <br /> | **[[2r83]] – hSYT1 C2A+C2B domains <br /> | ||
**[[5t0r]], [[5vfe]] – mSYT1 C2A domain – mouse <br /> | **[[5t0r]], [[5vfe]] – mSYT1 C2A domain – mouse <br /> | ||
| + | **[[5vff]], [[5vfg]], [[5t0s]] – mSYT1 C2B domain <br /> | ||
**[[1rsy]], [[4wee]] – rSYT1 C2A domain – rat <br /> | **[[1rsy]], [[4wee]] – rSYT1 C2A domain – rat <br /> | ||
**[[1k5w]], [[1byn]] – rSYT1 C2A domain - NMR<br /> | **[[1k5w]], [[1byn]] – rSYT1 C2A domain - NMR<br /> | ||
**[[1tjx]], [[1tjm]], [[1uov]], [[1uow]] – rSYT1 C2B domain <br /> | **[[1tjx]], [[1tjm]], [[1uov]], [[1uow]] – rSYT1 C2B domain <br /> | ||
**[[5ccj]] – rSYT1 C2B domain (mutant) <br /> | **[[5ccj]] – rSYT1 C2B domain (mutant) <br /> | ||
| - | **[[5vff]], [[5vfg]], [[5t0s]] – mSYT1 C2B domain <br /> | ||
*Synaptotagmin-1 complex | *Synaptotagmin-1 complex | ||
**[[2lha]] – hSYT1 C2B domain + inositol hexaphosphate - NMR<br /> | **[[2lha]] – hSYT1 C2B domain + inositol hexaphosphate - NMR<br /> | ||
| - | **[[2yoa]] – rSYT1 C2B domain + phosphoserine<br /> | ||
**[[4v11]] – hSYT1 C2B domain + synaptic vesicle glycoprotein peptide<br /> | **[[4v11]] – hSYT1 C2B domain + synaptic vesicle glycoprotein peptide<br /> | ||
**[[2k4a]] – hSYT1 C2A domain + heparin-binding growth factor - NMR<br /> | **[[2k4a]] – hSYT1 C2A domain + heparin-binding growth factor - NMR<br /> | ||
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**[[4isq]] – hSYT1 toxin-binding domain + botulinum neurotoxin DC heavy chain<br /> | **[[4isq]] – hSYT1 toxin-binding domain + botulinum neurotoxin DC heavy chain<br /> | ||
**[[2n1t]] – hSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25 <br /> | **[[2n1t]] – hSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25 <br /> | ||
| + | **[[2yoa]] – rSYT1 C2B domain + phosphoserine<br /> | ||
**[[5w5d]], [[5w5c]] – rSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25 + complexin-1<br /> | **[[5w5d]], [[5w5c]] – rSYT1 C2B domain + VAMP-2 + syntaxin-1A + SNAP-25 + complexin-1<br /> | ||
**[[5cch]], [[5ccg]], [[5kj7]], [[5cci]], [[5kj8]] – rSYT1 C2A+C2B domains + VAMP-2 + syntaxin-1A + SNAP-25 <br /> | **[[5cch]], [[5ccg]], [[5kj7]], [[5cci]], [[5kj8]] – rSYT1 C2A+C2B domains + VAMP-2 + syntaxin-1A + SNAP-25 <br /> | ||
| + | **[[6mti]] – rSYT1 C2A+C2B domains + VAMP-2 + syntaxin-1A + SNAP-25 – Cryo EM<br /> | ||
*Synaptotagmin-2 | *Synaptotagmin-2 | ||
| + | **[[4npk]], [[4npj]] – hSYT2 C2A+C2B domains 363-662<br /> | ||
| + | **[[4p42]] – hSYT2 SMP+C2A+C2B domains 191-662<br /> | ||
**[[2np0]], [[4kbb]] – mSYT2 ectodomain 1-60 + botulinum neurotoxin B<br /> | **[[2np0]], [[4kbb]] – mSYT2 ectodomain 1-60 + botulinum neurotoxin B<br /> | ||
**[[4isr]] – rSYT2 toxin-binding domain + botulinum neurotoxin DC heavy chain<br /> | **[[4isr]] – rSYT2 toxin-binding domain + botulinum neurotoxin DC heavy chain<br /> | ||
**[[2nm1]] – rSYT2 toxin-binding domain + botulinum neurotoxin B receptor-binding domain<br /> | **[[2nm1]] – rSYT2 toxin-binding domain + botulinum neurotoxin B receptor-binding domain<br /> | ||
| - | **[[4npk]], [[4npj]] – hSYT2 C2A+C2B domains 363-662<br /> | ||
| - | **[[4npi]] – hSYT2 SMP+C2A+C2B domains 191-662<br /> | ||
*Synaptotagmin-3 | *Synaptotagmin-3 | ||
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**[[2d8k]] – hSYT7 C2A domain - NMR<br /> | **[[2d8k]] – hSYT7 C2A domain - NMR<br /> | ||
**[[6anj]] – rSYT7 C2A domain <br /> | **[[6anj]] – rSYT7 C2A domain <br /> | ||
| - | **[[3n5a]] – mSYT7 C2B domain 266-403 <br /> | ||
**[[6ank]] – rSYT7 C2A+C2B domains <br /> | **[[6ank]] – rSYT7 C2A+C2B domains <br /> | ||
| + | **[[3n5a]] – mSYT7 C2B domain 266-403 <br /> | ||
*Synaptotagmin-13 | *Synaptotagmin-13 | ||
Revision as of 10:56, 12 February 2020
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3D structures of synaptotagmin
Updated on 12-February-2020
References
- ↑ Hu ZT, Chen MR, Ping Z, Dong YM, Zhang RY, Xu T, Wu ZX. Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. Biochem Biophys Res Commun. 2008 Jul 11;371(4):781-6. doi:, 10.1016/j.bbrc.2008.04.174. Epub 2008 May 9. PMID:18468511 doi:http://dx.doi.org/10.1016/j.bbrc.2008.04.174
- ↑ Xu J, Pang ZP, Shin OH, Sudhof TC. Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci. 2009 Jun;12(6):759-66. doi: 10.1038/nn.2320. PMID:19412166 doi:http://dx.doi.org/10.1038/nn.2320
- ↑ Zhang X, Rizo J, Sudhof TC. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry. 1998 Sep 8;37(36):12395-403. doi: 10.1021/bi9807512. PMID:9730811 doi:http://dx.doi.org/10.1021/bi9807512
- ↑ Chapman ER, Hanson PI, An S, Jahn R. Ca2+ regulates the interaction between synaptotagmin and syntaxin 1. J Biol Chem. 1995 Oct 6;270(40):23667-71. PMID:7559535
- ↑ Ohrfelt A, Brinkmalm A, Dumurgier J, Brinkmalm G, Hansson O, Zetterberg H, Bouaziz-Amar E, Hugon J, Paquet C, Blennow K. The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease. Alzheimers Res Ther. 2016 Oct 3;8(1):41. doi: 10.1186/s13195-016-0208-8. PMID:27716408 doi:http://dx.doi.org/10.1186/s13195-016-0208-8
- ↑ Xu J, Bacaj T, Zhou A, Tomchick DR, Sudhof TC, Rizo J. Structure and Ca-Binding Properties of the Tandem C Domains of E-Syt2. Structure. 2013 Dec 24. pii: S0969-2126(13)00461-9. doi:, 10.1016/j.str.2013.11.011. PMID:24373768 doi:http://dx.doi.org/10.1016/j.str.2013.11.011
