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T-cell receptor
From Proteopedia
(Difference between revisions)
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== Relevance == | == Relevance == | ||
Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy. | Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy. | ||
| + | == 3D structures of T-cell receptor== | ||
| + | [[T-cell receptor 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D structures of T-cell receptor== | == 3D structures of T-cell receptor== | ||
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*TCR α chain | *TCR α chain | ||
| - | **[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br /> | ||
**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br /> | **[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br /> | ||
**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br /> | **[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br /> | ||
| + | **[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br /> | ||
| + | **[[6mf8]] – mTCR α chain transmembrane domain - NMR<br /> | ||
*TCR β chain | *TCR β chain | ||
| - | **[[1bec]] – mTCR β chain <br /> | ||
**[[2axh]] – hTCR β chain (mutant) <br /> | **[[2axh]] – hTCR β chain (mutant) <br /> | ||
**[[2axj]] – hTCR β chain <br /> | **[[2axj]] – hTCR β chain <br /> | ||
**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br /> | **[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br /> | ||
| + | **[[1bec]] – mTCR β chain <br /> | ||
*TCR β chain + antigen | *TCR β chain + antigen | ||
| - | **[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br /> | ||
**[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br /> | **[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br /> | ||
**[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br /> | **[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br /> | ||
| + | **[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br /> | ||
*TCR δ chain | *TCR δ chain | ||
| Line 40: | Line 44: | ||
*TCR α+β chains | *TCR α+β chains | ||
| - | + | **[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]], [[6ovo]], [[6cuh]], [[6cph]], [[5nmd]] – hTCR α+β chains<br /> | |
| - | + | ||
| - | + | ||
| - | **[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]] – hTCR α+β chains<br /> | + | |
**[[4ei6]] – h/mTCR α+β chains <br /> | **[[4ei6]] – h/mTCR α+β chains <br /> | ||
**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br /> | **[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br /> | ||
**[[3of6]] – hTCR pre-α+β (mutant) chains<br /> | **[[3of6]] – hTCR pre-α+β (mutant) chains<br /> | ||
| + | **[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br /> | ||
| + | **[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br /> | ||
| + | **[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br /> | ||
*TCR α+β+γ chains | *TCR α+β+γ chains | ||
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*TCR complex with antigen | *TCR complex with antigen | ||
| - | **[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br /> | ||
**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br /> | **[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br /> | ||
**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br /> | **[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br /> | ||
| + | **[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br /> | ||
*TCR complex with MHC and antigen | *TCR complex with MHC and antigen | ||
| - | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]] | + | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]], [[4nqc]], [[4nqd]], [[4nqe]], [[6rpb]], [[6rpa]], [[6rp9]], [[6q3s]], [[6dkp]], [[5yxu]], [[5yxn]], [[5nqk]], [[5nmg]], [[5nmf]], [[5nme]], [[5nht]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> |
| - | + | **[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]], [[6u3o]], [[6u3n]], [[6py2]], [[6px6]], [[6cqr]], [[6cqq]], [[6cqn]], [[6cql]] – hTCR α+β chains + MHC + polypeptide <br /> | |
| - | **[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br /> | + | **[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]], [2iam]], [[2ian]], [[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> |
| - | **[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | + | |
**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br /> | **[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br /> | ||
**[[3pl6]] – hTCR α chain + MHC + polypeptide <br /> | **[[3pl6]] – hTCR α chain + MHC + polypeptide <br /> | ||
**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br /> | **[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br /> | ||
| - | **[[ | + | **[[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br /> |
| - | + | **[[1ypz]], [[6mwr]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | |
| - | **[[ | + | |
| - | + | ||
**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br /> | **[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br /> | ||
**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | **[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | ||
| - | **[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br /> | ||
**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | **[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | ||
| + | **[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br /> | ||
| + | **[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | **[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | ||
**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br /> | **[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br /> | ||
| - | **[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
| - | **[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | ||
| - | *TCR complex with | + | *TCR complex with CD |
**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br /> | **[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br /> | ||
| - | **[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br /> | + | **[[5wki]], [[6cug]] – hTCR α+β chains + β-2 microglobulin + CD1B <br /> |
**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br /> | **[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br /> | ||
**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | **[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | ||
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**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | **[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | ||
**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br /> | **[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br /> | ||
| + | **[[3t0e]] – hTCR α+β chains + MHC + CD4 <br /> | ||
| + | **[[6cxa]], [[6cx9]], [[6cx7]], [[6cx5]], [[6cwe]], [[6cwb]], [[6cw9]], [[6cw6]], [[5wlg]], [[5m02]] – mTCR α+β chains + β-2 microglobulin + CD1D1 <br /> | ||
}} | }} | ||
Revision as of 09:36, 16 February 2020
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3D structures of T-cell receptor
Updated on 16-February-2020
References
- ↑ Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11. PMID:17624994 doi:http://dx.doi.org/10.1111/j.1530-0277.2007.00452.x
- ↑ Uttenthal BJ, Chua I, Morris EC, Stauss HJ. Challenges in T cell receptor gene therapy. J Gene Med. 2012 Jun;14(6):386-99. doi: 10.1002/jgm.2637. PMID:22610778 doi:http://dx.doi.org/10.1002/jgm.2637
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