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6qja
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the NuMA N-terminal hook domain== | |
| - | + | <StructureSection load='6qja' size='340' side='right'caption='[[6qja]], [[Resolution|resolution]] 1.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qja OCA], [http://pdbe.org/6qja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qja RCSB], [http://www.ebi.ac.uk/pdbsum/6qja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qja ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Acute promyelocytic leukemia. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.<ref>PMID:19255246</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carminati, M]] | ||
[[Category: Mapelli, M]] | [[Category: Mapelli, M]] | ||
| - | [[Category: | + | [[Category: Hook domain]] |
| + | [[Category: Motor protein-associated]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 08:05, 5 February 2020
Crystal structure of the NuMA N-terminal hook domain
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