6sxw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)== | |
| - | + | <StructureSection load='6sxw' size='340' side='right'caption='[[6sxw]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SXW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sxw OCA], [http://pdbe.org/6sxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sxw RCSB], [http://www.ebi.ac.uk/pdbsum/6sxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sxw ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/ZN638_HUMAN ZN638_HUMAN]] Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).[UniProtKB:Q61464]<ref>PMID:30487602</ref> <ref>PMID:8647861</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Aitkenhead, H]] | [[Category: Aitkenhead, H]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N A]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A]] | ||
[[Category: Gileadi, O]] | [[Category: Gileadi, O]] | ||
| - | [[Category: Newman, J | + | [[Category: Newman, J A]] |
| - | [[Category: | + | [[Category: Wang, D]] |
| - | [[Category: | + | [[Category: Rna binding]] |
| + | [[Category: Rrm]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Zinc finger]] | ||
Revision as of 06:04, 16 October 2019
Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
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