Tumor necrosis factor receptor

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* '''TNFRSF 18''' is called '''GITRL''';<br />
* '''TNFRSF 18''' is called '''GITRL''';<br />
* '''TNFRSF 21''' is called '''Dr6''';<br />
* '''TNFRSF 21''' is called '''Dr6''';<br />
 +
* '''TNFRSF 25''' is called '''Dr3''';<br />
==See also [[Tumor necrosis factor ligand superfamily]]==
==See also [[Tumor necrosis factor ligand superfamily]]==
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== Structural highlights ==
== Structural highlights ==
The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
 +
==3D structures of tumor necrosis factor receptor==
 +
[[Tumor necrosis factor receptor 3D structures]]
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</StructureSection>
</StructureSection>
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*Tumor necrosis factor receptor superfamily-4 (OX40L receptor)
*Tumor necrosis factor receptor superfamily-4 (OX40L receptor)
-
**[[2hew]] – mTNFSF-4 extracellular domain - mouse<BR />
 
**[[2hev]] – hTNFSF-4 extracellular domain + OX40 ligand<BR />
**[[2hev]] – hTNFSF-4 extracellular domain + OX40 ligand<BR />
 +
**[[2hew]] – mTNFSF-4 extracellular domain - mouse<BR />
**[[2hey]] – mTNFSF-4 extracellular domain + hOX40 ligand<BR />
**[[2hey]] – mTNFSF-4 extracellular domain + hOX40 ligand<BR />
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**[[5wi8]], [[5wjf]] – hTNFSF-9 extracellular domain<BR />
**[[5wi8]], [[5wjf]] – hTNFSF-9 extracellular domain<BR />
**[[2x29]], [[5wiw]] – hTNFSF-9 extracellular domain (mutant)<BR />
**[[2x29]], [[5wiw]] – hTNFSF-9 extracellular domain (mutant)<BR />
-
**[[6cu0]], [[6cpr]], [[6bnv]] – hTNFSF-9 extracellular domain (mutant) + NSF ligand superfamily member 9<BR />
+
**[[6mkz]], [[6mgp]] – hTNFRSF-9 residues 24-160 + hTNFLS-9 residues 139-309<BR />
 +
**[[6cu0]], [[6cpr]], [[6bnv]], [[6bwv]] – hTNFSF-9 extracellular domain (mutant) + NSFLS9<BR />
 +
 
 +
*Tumor necrosis factor receptor superfamily-10A
 +
 
 +
**[[5cir]] – hTNFSF-10A extracellular domain + hTNFLS-10 residues 114-281<BR />
*Tumor necrosis factor receptor superfamily-10B (Dr5)
*Tumor necrosis factor receptor superfamily-10B (Dr5)
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**[[4i9x]] – hTNFRSF-10B extracellular domain + UL141<br />
**[[4i9x]] – hTNFRSF-10B extracellular domain + UL141<br />
**[[4n90]] – hTNFRSF-10B + hTNFRSF-10 + antibody <br />
**[[4n90]] – hTNFRSF-10B + hTNFRSF-10 + antibody <br />
 +
**[[6nhw]] – hTNFRSF-10B trasmembrane domain - NMR<br />
 +
**[[6nhy]] – hTNFRSF-10B trasmembrane domain (mutant) - NMR<br />
*Tumor necrosis factor receptor superfamily-11
*Tumor necrosis factor receptor superfamily-11
 +
**[[3urf]] – hTNFSF-11 receptor-binding domain + osteoprotegerin<BR />
**[[1jtz]], [[1iqa]], [[1s55]] – mTNFSF-11 receptor-binding domain<BR />
**[[1jtz]], [[1iqa]], [[1s55]] – mTNFSF-11 receptor-binding domain<BR />
**[[3me2]], [[3qbq]], [[4giq]] – mTNFSF-11 receptor-binding domain + RANK <BR />
**[[3me2]], [[3qbq]], [[4giq]] – mTNFSF-11 receptor-binding domain + RANK <BR />
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*Tumor necrosis factor receptor superfamily-14 (LIGHT)
*Tumor necrosis factor receptor superfamily-14 (LIGHT)
-
**[[4fhq]], [[4en0]] – hTNFRSF-14 extracellular domain <br />
+
**[[4fhq]], [[4en0]], [[5t2r]], [[5t2q]] – hTNFRSF-14 extracellular domain <br />
**[[2aw2]] – hTNFRSF-14 extracellular domain + B and T lymphocyte attenuator <br />
**[[2aw2]] – hTNFRSF-14 extracellular domain + B and T lymphocyte attenuator <br />
**[[4rsu]] – hTNFRSF-14 extracellular domain + TNFRSF-14 ligand<br />
**[[4rsu]] – hTNFRSF-14 extracellular domain + TNFRSF-14 ligand<br />
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**[[4f42]], [[4f44]] – hTNFRSF-16 death domain<br />
**[[4f42]], [[4f44]] – hTNFRSF-16 death domain<br />
**[[2n97]] – hTNFRSF-16 death domain - NMR<br />
**[[2n97]] – hTNFRSF-16 death domain - NMR<br />
 +
**[[5zgg]] – hTNFRSF-16 transmembrane domain + pyridine derivative - NMR<br />
**[[2mic]] – rTNFRSF-16 transmembrane domain – rat - NMR<br />
**[[2mic]] – rTNFRSF-16 transmembrane domain – rat - NMR<br />
**[[2mjo]] – rTNFRSF-16 transmembrane domain (mutant) - NMR<br />
**[[2mjo]] – rTNFRSF-16 transmembrane domain (mutant) - NMR<br />
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*Tumor necrosis factor receptor superfamily-18 (GITRL)
*Tumor necrosis factor receptor superfamily-18 (GITRL)
 +
**[[2q1m]], [[3b93]], [[3b94]] – hTNFRSF-18 extracellular domain <br />
 +
**[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
**[[4db5]] – TNFRSF-18 – rabbit <br />
**[[4db5]] – TNFRSF-18 – rabbit <br />
**[[4e4s]] – TNFRSF-18 – pika <br />
**[[4e4s]] – TNFRSF-18 – pika <br />
**[[4g4f]] – TNFRSF-18 – bushbaby <br />
**[[4g4f]] – TNFRSF-18 – bushbaby <br />
**[[3fc0]], [[2qdn]], [[3b9i]] – mTNFRSF-18 <br />
**[[3fc0]], [[2qdn]], [[3b9i]] – mTNFRSF-18 <br />
-
**[[2q1m]], [[3b93]], [[3b94]] – hTNFRSF-18 extracellular domain <br />
 
-
**[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
 
*Tumor necrosis factor receptor superfamily-21 (Dr6)
*Tumor necrosis factor receptor superfamily-21 (Dr6)
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**[[3qo4]] – hTNFRSF-21 cysteine-rich domain<br />
**[[3qo4]] – hTNFRSF-21 cysteine-rich domain<br />
**[[4yn0]] – hTNFRSF-21 cysteine-rich domain + amyloid beta A4 protein<br />
**[[4yn0]] – hTNFRSF-21 cysteine-rich domain + amyloid beta A4 protein<br />
 +
 +
*Tumor necrosis factor receptor superfamily-25 (Dr3)
 +
 +
**[[5ygs]] – hTNFRSF-25 death domain<br />
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**[[5ygp]] – hTNFRSF-25 death domain 9 (mutant)<br />
 +
**[[5yev]] – mTNFRSF-25 death domain<br />
 +
}}
}}
== References ==
== References ==

Revision as of 10:27, 15 March 2020

Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext).

Drag the structure with the mouse to rotate

3D structures of tumor necrosis factor receptor

Updated on 15-March-2020

References

  1. ↑ Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999;17:331-67. PMID:10358762 doi:http://dx.doi.org/10.1146/annurev.immunol.17.1.331
  2. ↑ Lopalco G, Rigante D, Vitale A, Frediani B, Iannone F, Cantarini L. Tumor necrosis factor receptor-associated periodic syndrome managed with the couple canakinumab-alendronate. Clin Rheumatol. 2015 Apr;34(4):807-9. doi: 10.1007/s10067-014-2556-8. Epub 2014, Mar 11. PMID:24609716 doi:http://dx.doi.org/10.1007/s10067-014-2556-8
  3. ↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750

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Michal Harel, Alexander Berchansky

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