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RNA Polymerase II
From Proteopedia
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== RNAP II == | == RNAP II == | ||
<StructureSection load='1i6h' size='340' side='right' caption='RNA Polymerase II''> | <StructureSection load='1i6h' size='340' side='right' caption='RNA Polymerase II''> | ||
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== Structural Components == | == Structural Components == | ||
The <scene name='82/824648/Clamp/2'>clamp</scene> swings to trap the DNA in the cleft. Further along, the <scene name='82/824648/Wall/1'>wall</scene> sends the DNA template through the cleft in approximately a 90° turn. Both the clamp and wall are parts of the Rpb2 subunit. Further along in the process, the <scene name='82/824648/Rudder/1'>rudder</scene> separates the newly synthesized RNA strand from the DNA template. The DNA reforms into a double helix as it leaves RNA pol II. | The <scene name='82/824648/Clamp/2'>clamp</scene> swings to trap the DNA in the cleft. Further along, the <scene name='82/824648/Wall/1'>wall</scene> sends the DNA template through the cleft in approximately a 90° turn. Both the clamp and wall are parts of the Rpb2 subunit. Further along in the process, the <scene name='82/824648/Rudder/1'>rudder</scene> separates the newly synthesized RNA strand from the DNA template. The DNA reforms into a double helix as it leaves RNA pol II. | ||
Revision as of 19:32, 6 October 2019
Contents |
RNAP II
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References
Bushnell, D. A.; Westover, K. D.; Davis, R. E.; Kornberg, R. D. Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms. Science. 2004, 303, 983-988 Cramer, P.; Bushnell, D. A.; Kornberg, R. D. Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution. Science. 2001, 292, 1863-1876 Uzman, A.; Voet, D. Student companion Fundamentals of biochemistry: life at the molecular level, 4th ed., Donald Voet, Judith G. Voet, Charlotte W. Pratt; John Wiley & amp; Sons, 2012. Evans, D. A.; Fitch, D. M.; Smith, T. E.; Cee, V. J. Application of Complex Aldol Reactions to the Total Synthesis of Phorboxazole B. J. Am. Chem. Soc. 2000, 122, 10033-10046.
Notes
From structural components: Bridge: Depicted: [PDB: 1I6H: 810-845.a] Wall: Depicted: [PDB: 1R5U: 853-919.b; 933-972.b] Clamp: Depicted: [PDB: 1R5U: 3-345.a; 1395-1435.a; 1158-1124.b] Rudder: Depicted: [PDB: 5VVR: 306-321.a]
Content Donators
This page was created as a final project for the Advanced Biochemistry course at Wabash College during the Fall of 2019. This page was reviewed by Dr. Wally Novak of Wabash College.
Proteopedia Page Contributors and Editors (what is this?)
Titus Edwards, Abraham Kiesel, Wally Novak, James Daniel Andry, Michal Harel, Karsten Theis
