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6rtx

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Current revision (12:28, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rtx' size='340' side='right'caption='[[6rtx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6rtx' size='340' side='right'caption='[[6rtx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rtx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rtx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RTX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTCH1, PTCH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtx OCA], [http://pdbe.org/6rtx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtx RCSB], [http://www.ebi.ac.uk/pdbsum/6rtx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtx OCA], [https://pdbe.org/6rtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rtx RCSB], [https://www.ebi.ac.uk/pdbsum/6rtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtx ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rtx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rtx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein patched homolog 1|Protein patched homolog 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ansell, T B]]
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[[Category: Ansell TB]]
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[[Category: Bishop, B]]
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[[Category: Bishop B]]
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[[Category: Covey, D F]]
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[[Category: Covey DF]]
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[[Category: Duman, R]]
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[[Category: Duman R]]
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[[Category: Kinnebrew, M]]
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[[Category: El Omari K]]
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[[Category: Kowatsch, C]]
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[[Category: Kinnebrew M]]
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[[Category: Malinauskas, T]]
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[[Category: Kowatsch C]]
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[[Category: Omari, K El]]
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[[Category: Malinauskas T]]
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[[Category: Pardon, E]]
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[[Category: Pardon E]]
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[[Category: Qian, M]]
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[[Category: Qian M]]
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[[Category: Rohatgi, R]]
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[[Category: Rohatgi R]]
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[[Category: Rudolf, A F]]
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[[Category: Rudolf AF]]
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[[Category: Sansom, M S.P]]
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[[Category: Sansom MSP]]
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[[Category: Schwab, R A]]
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[[Category: Schwab RA]]
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[[Category: Siebold, C]]
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[[Category: Siebold C]]
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[[Category: Steyaert, J]]
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[[Category: Steyaert J]]
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[[Category: Wagner, A]]
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[[Category: Wagner A]]
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[[Category: Hedgehog morphogen receptor]]
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[[Category: Cholesterol]]
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[[Category: Lipid-protein-modification]]
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[[Category: Membrane protein]]
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[[Category: Palmitate]]
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[[Category: Receptor-nanobody complex]]
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Current revision

Crystal structure of the Patched-1 (PTCH1) ectodomain 1

PDB ID 6rtx

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