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6rtw

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Current revision (12:28, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rtw' size='340' side='right'caption='[[6rtw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6rtw' size='340' side='right'caption='[[6rtw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rtw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rtw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RTW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTCH1, PTCH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtw OCA], [http://pdbe.org/6rtw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rtw RCSB], [http://www.ebi.ac.uk/pdbsum/6rtw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rtw OCA], [https://pdbe.org/6rtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rtw RCSB], [https://www.ebi.ac.uk/pdbsum/6rtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rtw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rtw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rtw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein patched homolog 1|Protein patched homolog 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Camelus glama]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ansell, T B]]
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[[Category: Ansell TB]]
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[[Category: Bishop, B]]
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[[Category: Bishop B]]
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[[Category: Covey, D F]]
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[[Category: Covey DF]]
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[[Category: Duman, R]]
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[[Category: Duman R]]
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[[Category: Kinnebrew, M]]
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[[Category: El Omari K]]
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[[Category: Kowatsch, C]]
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[[Category: Kinnebrew M]]
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[[Category: Malinauskas, T]]
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[[Category: Kowatsch C]]
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[[Category: Omari, K El]]
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[[Category: Malinauskas T]]
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[[Category: Pardon, E]]
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[[Category: Pardon E]]
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[[Category: Qian, M]]
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[[Category: Qian M]]
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[[Category: Rohatgi, R]]
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[[Category: Rohatgi R]]
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[[Category: Rudolf, A F]]
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[[Category: Rudolf AF]]
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[[Category: Sansom, M S.P]]
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[[Category: Sansom MSP]]
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[[Category: Schwab, R A]]
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[[Category: Schwab RA]]
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[[Category: Siebold, C]]
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[[Category: Siebold C]]
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[[Category: Steyaert, J]]
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[[Category: Steyaert J]]
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[[Category: Wagner, A]]
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[[Category: Wagner A]]
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[[Category: Hedgehog morphogen receptor]]
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[[Category: Cholesterol]]
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[[Category: Lipid-protein-modification]]
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[[Category: Membrane protein]]
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[[Category: Palmitate]]
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[[Category: Receptor-nanobody complex]]
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Current revision

Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate

PDB ID 6rtw

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