Uridine 5'-monophosphate synthase
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
*Uridine 5’-monophosphate synthase OMP decarboxylase subunit | *Uridine 5’-monophosphate synthase OMP decarboxylase subunit | ||
| - | **[[3gdk]] - yOPD – yeast<br /> | ||
| - | **[[1dqw]], [[3gdr]], [[3gdm]] – yOPD (mutant) <br /> | ||
**[[2eaw]], [[2jgy]], [[2p1f]], [[2qcc]], [[2qce]] - hOPD – human<br /> | **[[2eaw]], [[2jgy]], [[2p1f]], [[2qcc]], [[2qce]] - hOPD – human<br /> | ||
| + | **[[3gdk]] - yOPD – yeast<br /> | ||
| + | **[[1dqw]], [[3gdr]], [[3gdm]] – yOPD (mutant) <br />> | ||
**[[4n2y]] – AfOPD – ''Archaeoglobus fulgidus''<br /> | **[[4n2y]] – AfOPD – ''Archaeoglobus fulgidus''<br /> | ||
**[[4lui]] – MjOPD – ''Methanocaldococcus jannaschii''<br /> | **[[4lui]] – MjOPD – ''Methanocaldococcus jannaschii''<br /> | ||
| Line 64: | Line 64: | ||
**[[3bvj]] - hOPD + XMP<br /> | **[[3bvj]] - hOPD + XMP<br /> | ||
**[[3bgg]], [[3ex4]] - hOPD + BMP<br /> | **[[3bgg]], [[3ex4]] - hOPD + BMP<br /> | ||
| + | **[[1dqx]] – yOPD (mutant) + BMP <br /> | ||
**[[4lw7]], [[3ltp]], [[4luj]], [[1lor]] – MtOPD + BMP <br /> | **[[4lw7]], [[3ltp]], [[4luj]], [[1lor]] – MtOPD + BMP <br /> | ||
**[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]], [[1x1z]], [[3lht]], [[3lhu]], [[3lhv]], [[3lhw]], [[3lhy]], [[3lhz]], [[3li0]], [[3li1]], [[3lts]], [[3lty]], [[3lv5]], [[3lv6]], [[3m1z]], [[3nq7]], [[3nqa]], [[3nqc]], [[3nqd]], [[3nqe]], [[3nqf]], [[3nqg]], [[3nqm]], [[3p5y]], [[3p5z]], [[3p60]], [[3p61]], [[3qez]], [[3qf0]], [[3qmr]], [[3qms]], [[3qmt]], [[3rlu]], [[3rlv]], [[3siz]], [[3sj3]], [[3v1p]], [[4lw7]], [[2zz1]] – MtOPD (mutant) + BMP <br /> | **[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]], [[1x1z]], [[3lht]], [[3lhu]], [[3lhv]], [[3lhw]], [[3lhy]], [[3lhz]], [[3li0]], [[3li1]], [[3lts]], [[3lty]], [[3lv5]], [[3lv6]], [[3m1z]], [[3nq7]], [[3nqa]], [[3nqc]], [[3nqd]], [[3nqe]], [[3nqf]], [[3nqg]], [[3nqm]], [[3p5y]], [[3p5z]], [[3p60]], [[3p61]], [[3qez]], [[3qf0]], [[3qmr]], [[3qms]], [[3qmt]], [[3rlu]], [[3rlv]], [[3siz]], [[3sj3]], [[3v1p]], [[4lw7]], [[2zz1]] – MtOPD (mutant) + BMP <br /> | ||
| Line 77: | Line 78: | ||
**[[3vi2]] - PfOPD + inhibitor<br /> | **[[3vi2]] - PfOPD + inhibitor<br /> | ||
**[[2za1]] - PfOPD + OMP <br /> | **[[2za1]] - PfOPD + OMP <br /> | ||
| - | **[[1dqx]] – yOPD (mutant) + BMP <br /> | ||
*Uridine 5’-monophosphate synthase OPRT subunit see orotate phosphoribosyltransferase in [[Phosphoribosyltransferase]] | *Uridine 5’-monophosphate synthase OPRT subunit see orotate phosphoribosyltransferase in [[Phosphoribosyltransferase]] | ||
Revision as of 08:40, 23 March 2020
| |||||||||||
3D structures of uridine 5'-monophosphate synthase
Updated on 23-March-2020
References
- ↑ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase. J Biol Chem. 1996 May 3;271(18):10704-8. PMID:8631878
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G. Hereditary orotic aciduria with epilepsy and without megaloblastic anemia. Neuropediatrics. 2015 Apr;46(2):123-5. doi: 10.1055/s-0035-1547341. Epub 2015 Mar, 10. PMID:25757096 doi:http://dx.doi.org/10.1055/s-0035-1547341
- ↑ Schwenger B, Schober S, Simon D. DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene. Genomics. 1993 Apr;16(1):241-4. PMID:8486364 doi:http://dx.doi.org/10.1006/geno.1993.1165
- ↑ Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure. 2008 Jan;16(1):82-92. PMID:18184586 doi:http://dx.doi.org/10.1016/j.str.2007.10.020
