6t1n
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 5== | |
| - | + | <StructureSection load='6t1n' size='340' side='right'caption='[[6t1n]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6t1n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T1N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M7Z:4-chloranyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide'>M7Z</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1n OCA], [http://pdbe.org/6t1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t1n RCSB], [http://www.ebi.ac.uk/pdbsum/6t1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1n ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brennan, P E]] | ||
[[Category: Chaikuad, A]] | [[Category: Chaikuad, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Fedorov, O]] | ||
[[Category: Heidenreich, D]] | [[Category: Heidenreich, D]] | ||
[[Category: Knapp, S]] | [[Category: Knapp, S]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
| - | [[Category: Brennan, P.E]] | ||
| - | [[Category: Fedorov, O]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
| - | [[Category: Bountra, C]] | ||
[[Category: Moustakim, M]] | [[Category: Moustakim, M]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Chemical probe]] | ||
| + | [[Category: Enl]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Mllt1]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Yeats domain]] | ||
Revision as of 06:54, 6 November 2019
Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 5
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Categories: Large Structures | Arrowsmith, C H | Bountra, C | Brennan, P E | Chaikuad, A | Edwards, A M | Fedorov, O | Heidenreich, D | Knapp, S | Moustakim, M | Structural genomic | Chemical probe | Enl | Inhibitor | Mllt1 | Sgc | Transcription | Yeats domain
