3bze

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3bze", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3bze.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bze.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bze| PDB=3bze | SCENE= }}
{{STRUCTURE_3bze| PDB=3bze | SCENE= }}
-
'''The human non-classical major histocompatibility complex molecule HLA-E'''
+
===The human non-classical major histocompatibility complex molecule HLA-E===
-
==Overview==
+
<!--
-
Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I molecule that binds peptides derived from the leader sequences of other HLA class I molecules. Natural killer cell recognition of these HLA-E molecules, via the CD94-NKG2 natural killer family, represents a central innate mechanism for monitoring major histocompatibility complex expression levels within a cell. The leader sequence-derived peptides bound to HLA-E exhibit very limited polymorphism, yet subtle differences affect the recognition of HLA-E by the CD94-NKG2 receptors. To better understand the basis for this peptide-specific recognition, we determined the structure of HLA-E in complex with two leader peptides, namely, HLA-Cw*07 (VMAPRALLL), which is poorly recognised by CD94-NKG2 receptors, and HLA-G*01 (VMAPRTLFL), a high-affinity ligand of CD94-NKG2 receptors. A comparison of these structures, both of which were determined to 2.5-A resolution, revealed that allotypic variations in the bound leader sequences do not result in conformational changes in the HLA-E heavy chain, although subtle changes in the conformation of the peptide within the binding groove of HLA-E were evident. Accordingly, our data indicate that the CD94-NKG2 receptors interact with HLA-E in a manner that maximises the ability of the receptors to discriminate between subtle changes in both the sequence and conformation of peptides bound to HLA-E.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18339401}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18339401 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18339401}}
==About this Structure==
==About this Structure==
Line 43: Line 47:
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:34:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:28:20 2008''

Revision as of 11:28, 29 July 2008

Image:3bze.png

Template:STRUCTURE 3bze

The human non-classical major histocompatibility complex molecule HLA-E

Template:ABSTRACT PUBMED 18339401

About this Structure

3BZE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors., Hoare HL, Sullivan LC, Clements CS, Ely LK, Beddoe T, Henderson KN, Lin J, Reid HH, Brooks AG, Rossjohn J, J Mol Biol. 2008 Apr 11;377(5):1297-303. Epub 2008 Feb 12. PMID:18339401

Page seeded by OCA on Tue Jul 29 14:28:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bze"
Personal tools