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4x2a

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<StructureSection load='4x2a' size='340' side='right'caption='[[4x2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4x2a' size='340' side='right'caption='[[4x2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x2a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X2A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3WL:5,6,7-TRIHYDROXY-2-PHENYL-4H-CHROMEN-4-ONE'>3WL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3WL:5,6,7-TRIHYDROXY-2-PHENYL-4H-CHROMEN-4-ONE'>3WL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2za0|2za0]], [[4kyk|4kyk]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2a OCA], [https://pdbe.org/4x2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x2a RCSB], [https://www.ebi.ac.uk/pdbsum/4x2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2a ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Glo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2a OCA], [http://pdbe.org/4x2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x2a RCSB], [http://www.ebi.ac.uk/pdbsum/4x2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2a ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
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[https://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lactoylglutathione lyase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Hu, X]]
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[[Category: Hu X]]
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[[Category: Li, C]]
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[[Category: Li C]]
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[[Category: Zhai, J]]
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[[Category: Zhai J]]
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[[Category: Zhang, H]]
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[[Category: Zhang H]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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Revision as of 21:07, 12 April 2023

Crystal structure of mouse glyoxalase I complexed with baicalein

PDB ID 4x2a

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