This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

5nlb

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5nlb"

@@ Line 3: / Line 3: @@
 <StructureSection load='5nlb' size='340' side='right'caption='[[5nlb]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5nlb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NLB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5nlb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NLB FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CUL3, KIAA0617 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nlb OCA], [http://pdbe.org/5nlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nlb RCSB], [http://www.ebi.ac.uk/pdbsum/5nlb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nlb ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nlb OCA], [https://pdbe.org/5nlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nlb RCSB], [https://www.ebi.ac.uk/pdbsum/5nlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nlb ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/CUL3_HUMAN CUL3_HUMAN]] Pseudohypoaldosteronism type 2E. Defects in CUL3 are the cause of Pseudohypoaldosteronism type 2E (PHA2E) [MIM:[http://omim.org/entry/614496 614496]]. An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics.<ref>PMID:22266938</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/CUL3_HUMAN CUL3_HUMAN]] Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; possibly by mediating ubiquitination of SLC12A3/NCC. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition.<ref>PMID:10500095</ref> <ref>PMID:11311237</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref> <ref>PMID:17543862</ref> <ref>PMID:22358839</ref>
+[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
 ==See Also==
@@ Line 16: / Line 14: @@
 *[[Galectin 3D structures|Galectin 3D structures]]
 *[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Adamson, R]]
+[[Category: Adamson R]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Bartual, S G]]
+[[Category: Bartual SG]]
-[[Category: Borkowska, O]]
+[[Category: Borkowska O]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Bullock, A]]
+[[Category: Bullock A]]
-[[Category: Burgess-Brown, N A]]
+[[Category: Burgess-Brown NA]]
-[[Category: Chalk, R]]
+[[Category: Chalk R]]
-[[Category: Delft, F von]]
+[[Category: Dixon-Clarke SE]]
-[[Category: Dixon-Clarke, S E]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M]]
+[[Category: Kopec J]]
-[[Category: Kopec, J]]
+[[Category: Krojer T]]
-[[Category: Krojer, T]]
+[[Category: Mackinnon S]]
-[[Category: Mackinnon, S]]
+[[Category: Mathea S]]
-[[Category: Mathea, S]]
+[[Category: Newman JA]]
-[[Category: Newman, J A]]
+[[Category: Pinkas DM]]
-[[Category: Pinkas, D M]]
+[[Category: Sethi R]]
-[[Category: Sethi, R]]
+[[Category: Velupillai S]]
-[[Category: Velupillai, S]]
+[[Category: Von Delft F]]
-[[Category: E3 ubiquitin ligase]]
-[[Category: Ligase]]

5nlb

From Proteopedia

Current revision

Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box

Structural highlights

Function

See Also

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox