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6pon

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Current revision (07:32, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6pon' size='340' side='right'caption='[[6pon]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6pon' size='340' side='right'caption='[[6pon]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pon]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PON FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PON FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pavA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.395&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pon OCA], [http://pdbe.org/6pon PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pon RCSB], [http://www.ebi.ac.uk/pdbsum/6pon PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pon ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pon OCA], [https://pdbe.org/6pon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pon RCSB], [https://www.ebi.ac.uk/pdbsum/6pon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pon ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RQCH_STRR6 RQCH_STRR6] Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.[HAMAP-Rule:MF_00844] Recombinant protein binds to immobilized human fibronectin; binding is saturable and competed by heparin. Recombinant protein inhibits binding of whole cells to fibronectin.<ref>PMID:11580843</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Manne, K]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Narayana, S V.L]]
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[[Category: Manne K]]
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[[Category: Cell adhesion]]
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[[Category: Narayana SVL]]
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[[Category: Fibronectin-binding protein]]
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[[Category: Pava]]
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[[Category: Pneumococcal adherence and virulence factor some]]
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Current revision

CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF FIBRONECTIN- BINDING PROTEIN PAVA FROM STREPTOCOCCUS PNEUMONIAE

PDB ID 6pon

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OCA

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