2z32

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{{STRUCTURE_2z32| PDB=2z32 | SCENE= }}
{{STRUCTURE_2z32| PDB=2z32 | SCENE= }}
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'''Crystal structure of Keap1 complexed with Prothymosin alpha'''
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===Crystal structure of Keap1 complexed with Prothymosin alpha===
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==Overview==
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The Nrf2 transcription factor, which plays important roles in oxidative and xenobiotic stress, is negatively regulated by the cytoplasmic repressor Keap1. The beta-propeller/Kelch domain of Keap1, which is formed by the double-glycine repeat and C-terminal region domains (Keap1-DC), interacts directly with the Neh2 domain of Nrf2. The nuclear oncoprotein prothymosin alpha (ProTalpha) also interacts directly with Keap1 and may play a role in the dissociation of the Keap1-Nrf2 complex. The structure of Keap1-DC complexed with a ProTalpha peptide (amino acids 39-54) has been determined at 1.9 A resolution. The Keap1-bound ProTalpha peptide possesses a hairpin conformation and binds to the Keap1 protein at the bottom region of the beta-propeller domain. Complex formation occurs as a consequence of their complementary electrostatic interactions. A comparison of the present structure with recently reported Keap1-DC complex structures revealed that the DLG and ETGE motifs of the Neh2 domain of Nrf2 and the ProTalpha peptide bind to Keap1 in a similar manner but with different binding potencies.
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(as it appears on PubMed at http://www.pubmed.gov), where 18391415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18391415}}
==About this Structure==
==About this Structure==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:35:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:02:16 2008''

Revision as of 10:02, 28 July 2008

Image:2z32.png

Template:STRUCTURE 2z32

Crystal structure of Keap1 complexed with Prothymosin alpha

Template:ABSTRACT PUBMED 18391415

About this Structure

2Z32 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural analysis of the complex of Keap1 with a prothymosin alpha peptide., Padmanabhan B, Nakamura Y, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):233-8. Epub 2008 Mar 21. PMID:18391415

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