This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2z32

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2z32.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2z32.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2z32| PDB=2z32 | SCENE= }}
{{STRUCTURE_2z32| PDB=2z32 | SCENE= }}
-
'''Crystal structure of Keap1 complexed with Prothymosin alpha'''
+
===Crystal structure of Keap1 complexed with Prothymosin alpha===
-
==Overview==
+
<!--
-
The Nrf2 transcription factor, which plays important roles in oxidative and xenobiotic stress, is negatively regulated by the cytoplasmic repressor Keap1. The beta-propeller/Kelch domain of Keap1, which is formed by the double-glycine repeat and C-terminal region domains (Keap1-DC), interacts directly with the Neh2 domain of Nrf2. The nuclear oncoprotein prothymosin alpha (ProTalpha) also interacts directly with Keap1 and may play a role in the dissociation of the Keap1-Nrf2 complex. The structure of Keap1-DC complexed with a ProTalpha peptide (amino acids 39-54) has been determined at 1.9 A resolution. The Keap1-bound ProTalpha peptide possesses a hairpin conformation and binds to the Keap1 protein at the bottom region of the beta-propeller domain. Complex formation occurs as a consequence of their complementary electrostatic interactions. A comparison of the present structure with recently reported Keap1-DC complex structures revealed that the DLG and ETGE motifs of the Neh2 domain of Nrf2 and the ProTalpha peptide bind to Keap1 in a similar manner but with different binding potencies.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18391415}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18391415 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18391415}}
==About this Structure==
==About this Structure==
Line 42: Line 46:
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:35:47 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:02:16 2008''

Revision as of 10:02, 28 July 2008

Image:2z32.png

Template:STRUCTURE 2z32

Crystal structure of Keap1 complexed with Prothymosin alpha

Template:ABSTRACT PUBMED 18391415

About this Structure

2Z32 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural analysis of the complex of Keap1 with a prothymosin alpha peptide., Padmanabhan B, Nakamura Y, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):233-8. Epub 2008 Mar 21. PMID:18391415

Page seeded by OCA on Mon Jul 28 13:02:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z32"
Personal tools