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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
The N-terminal tails of core histones in a nucleosome core particle (NCP) aid in a multitude of functions such as structural stability, thermal stability, and the stimulation of transcription binding factors.[3]
Importance
The N-terminal tail interactions of the H4 histone are crucial in order to correctly fold the nucleosomes into compact units that can be used to form chromatin fibers. This interaction occurs on the G14 to R19 or K16 to N25 residues that reside on the N-terminal tail of H4 and the acidic patch of the neighboring nucleosome. [4]
Relevance
Through various observations, the scientists have presumed that the acetylation of the nucleosome itself is what regulates the decompaction of the higher-order chromatin structure, even in the absence of chromatin- associated factors. [5]
Structural highlights
Below are the various structural highlight of the H4-tetra-acetylated NCP:
displays in green the molecule B which is composed of residues 1-20 while the color yellow represents the molecule F which highlights residues 1-15.
show the H4 nucleosome in its unaltered state.
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S. Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation. Sci Rep. 2015 Nov 26;5:17204. doi: 10.1038/srep17204. PMID:26607036 doi:http://dx.doi.org/10.1038/srep17204
- ↑ Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S. Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation. Sci Rep. 2015 Nov 26;5:17204. doi: 10.1038/srep17204. PMID:26607036 doi:http://dx.doi.org/10.1038/srep17204
- ↑ Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S. Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation. Sci Rep. 2015 Nov 26;5:17204. doi: 10.1038/srep17204. PMID:26607036 doi:http://dx.doi.org/10.1038/srep17204
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