6syt

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'''Unreleased structure'''
 
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The entry 6syt is ON HOLD until Paper Publication
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==Structure of the SMG1-SMG8-SMG9 complex==
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<StructureSection load='6syt' size='340' side='right'caption='[[6syt]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6syt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SYT FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6syt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6syt OCA], [http://pdbe.org/6syt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6syt RCSB], [http://www.ebi.ac.uk/pdbsum/6syt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6syt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/SMG9_HUMAN SMG9_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).[UniProtKB:Q9DB90]<ref>PMID:19417104</ref> [[http://www.uniprot.org/uniprot/SMG8_HUMAN SMG8_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.<ref>PMID:19417104</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Conti, E]]
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[[Category: Gat, Y]]
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[[Category: Schuller, J M]]
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[[Category: G-fold protein]]
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[[Category: Ip6]]
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[[Category: Kinase]]
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[[Category: Nmd]]
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[[Category: Pikk family]]
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[[Category: Signaling protein]]

Revision as of 15:23, 11 December 2019

Structure of the SMG1-SMG8-SMG9 complex

PDB ID 6syt

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