This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ht5
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6ht5' size='340' side='right'caption='[[6ht5]], [[Resolution|resolution]] 3.45Å' scene=''> | <StructureSection load='6ht5' size='340' side='right'caption='[[6ht5]], [[Resolution|resolution]] 3.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ht5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT5 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6ht5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HT5 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.451Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ht5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht5 OCA], [https://pdbe.org/6ht5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ht5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ht5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SOX2_MOUSE SOX2_MOUSE] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:17097055</ref> <ref>PMID:22198669</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[OCT4 and SOX2 transcription factors|OCT4 and SOX2 transcription factors]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 13: | Line 17: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Groves | + | [[Category: Mus musculus]] |
| - | [[Category: Meusch | + | [[Category: Groves M]] |
| - | [[Category: Pogenberg | + | [[Category: Meusch D]] |
| - | [[Category: Vahokoski | + | [[Category: Pogenberg V]] |
| - | [[Category: Wilmanns | + | [[Category: Vahokoski J]] |
| - | + | [[Category: Wilmanns M]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Oct4/Sox2:UTF1 structure
| |||||||||||
