MECDP synthase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='52/526157/Cv/7'>MECPS active site is located in a cleft between 2 subunits</scene> and contains the <scene name='52/526157/Cv/8'>metal ions</scene><ref>PMID:11997478</ref>. Water molecules are shown as red spheres. | <scene name='52/526157/Cv/7'>MECPS active site is located in a cleft between 2 subunits</scene> and contains the <scene name='52/526157/Cv/8'>metal ions</scene><ref>PMID:11997478</ref>. Water molecules are shown as red spheres. | ||
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| + | ==3D structures of MECDP synthase== | ||
| + | [[MECDP synthase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of MECDP synthase== | ==3D structures of MECDP synthase== | ||
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**[[1u3p]] - EcMECPS + Zn<br /> | **[[1u3p]] - EcMECPS + Zn<br /> | ||
**[[3f0d]] - BpMECPS + Zn – ''Burkholderia pseudomallei''<br /> | **[[3f0d]] - BpMECPS + Zn – ''Burkholderia pseudomallei''<br /> | ||
| + | **[[5l12]] - BpMECPS (mutant) + Zn<br /> | ||
**[[3f0e]] - BpMECPS + Mg + Zn<br /> | **[[3f0e]] - BpMECPS + Mg + Zn<br /> | ||
**[[1jn1]] - HiMECPS + Co – ''Haemophilus influenzae'' <br /> | **[[1jn1]] - HiMECPS + Co – ''Haemophilus influenzae'' <br /> | ||
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**[[3ike]] - BpMECPS + cytosine + Mg + Zn<br /> | **[[3ike]] - BpMECPS + cytosine + Mg + Zn<br /> | ||
**[[3k2x]], [[3ke1]] - BpMECPS + cytosine derivative + Zn<br /> | **[[3k2x]], [[3ke1]] - BpMECPS + cytosine derivative + Zn<br /> | ||
| + | **[[5l03]] - BpMECPS + Trp derivative + Zn<br /> | ||
**[[3ikf]], [[3k14]], [[3q8h]] - BpMECPS + imidazo-thiazol derivative + Zn<br /> | **[[3ikf]], [[3k14]], [[3q8h]] - BpMECPS + imidazo-thiazol derivative + Zn<br /> | ||
**[[3f0g]], [[3ieq]] - BpMECPS + CMP + Zn<br /> | **[[3f0g]], [[3ieq]] - BpMECPS + CMP + Zn<br /> | ||
Revision as of 10:43, 29 October 2019
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3D structures of MECDP synthase
Updated on 29-October-2019
References
- ↑ Richard SB, Ferrer JL, Bowman ME, Lillo AM, Tetzlaff CN, Cane DE, Noel JP. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J Biol Chem. 2002 Mar 8;277(10):8667-72. Epub 2002 Jan 10. PMID:11786530 doi:http://dx.doi.org/10.1074/jbc.C100739200
- ↑ Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY. Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):23-31. Epub 2002, Dec 19. PMID:12499535
- ↑ Kemp LE, Bond CS, Hunter WN. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6591-6. Epub 2002 May 7. PMID:11997478 doi:10.1073/pnas.102679799
