MECDP synthase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of MECDP synthase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''MECPS''' | ||
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| - | **[[1knk]] - EcMECPS + Mn – ''Escherichia coli''<br /> | ||
| - | **[[1u3p]] - EcMECPS + Zn<br /> | ||
| - | **[[3f0d]] - BpMECPS + Zn – ''Burkholderia pseudomallei''<br /> | ||
| - | **[[5l12]] - BpMECPS (mutant) + Zn<br /> | ||
| - | **[[3f0e]] - BpMECPS + Mg + Zn<br /> | ||
| - | **[[1jn1]] - HiMECPS + Co – ''Haemophilus influenzae'' <br /> | ||
| - | **[[1vh8]] - HiMECPS <br /> | ||
| - | **[[1vha]] - HiMECPS + Mn<br /> | ||
| - | **[[1iv1]] - TtMECPS – ''Thermus thermophilus''<br /> | ||
| - | **[[3f6m]] - YpMECPS – ''Yersinia pestis''<br /> | ||
| - | **[[1iv3]] - TtMECPS (mutant) + Mg<br /> | ||
| - | **[[3ghz]] - MECPS + Mg – ''Salmonella typhimurium''<br /> | ||
| - | **[[3re3]] - MECPS – ''Francisella tularensis''<br /> | ||
| - | **[[4c82]] - PfMECPS (mutant) + Zn – ''Plasmodium falciparum''<br /> | ||
| - | **[[5iwx]] - BsMECPS + Mg – ''Bacillus subtilis''<br /> | ||
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| - | *MECPS binary complex | ||
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| - | **[[1gx1]] - EcMECPS + CDP + Mn + Zn<br /> | ||
| - | **[[1u3l]] - EcMECPS + CDP + Mg + Zn<br /> | ||
| - | **[[3f0f]] - BpMECPS + CMP + Mg + Zn<br /> | ||
| - | **[[3ike]] - BpMECPS + cytosine + Mg + Zn<br /> | ||
| - | **[[3k2x]], [[3ke1]] - BpMECPS + cytosine derivative + Zn<br /> | ||
| - | **[[5l03]] - BpMECPS + Trp derivative + Zn<br /> | ||
| - | **[[3ikf]], [[3k14]], [[3q8h]] - BpMECPS + imidazo-thiazol derivative + Zn<br /> | ||
| - | **[[3f0g]], [[3ieq]] - BpMECPS + CMP + Zn<br /> | ||
| - | **[[2uzh]] - MECPS + CDP + Zn – ''Mycobacterium smegmatis''<br /> | ||
| - | **[[4c81]] - PfMECPS (mutant) + CDP + Zn <br /> | ||
| - | **[[3fpi]] - YpMECPS + CTP + Mg<br /> | ||
| - | **[[5b8f]] - MECPS + CMP + Mg – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[5iwy]] - BsMECPS + CMP + Mg <br /> | ||
| - | **[[1iv2]] - TtMECPS (mutant) + CDP + Mg<br /> | ||
| - | **[[1iv4]] - TtMECPS (mutant) + CMP + Mg<br /> | ||
| - | **[[1h47]] - EcMECPS + CMP + Zn<br /> | ||
| - | **[[3jvh]] - BpMECPS + pyrimidine derivative + Zn<br /> | ||
| - | **[[1u40]] - EcMECPS + CDME + Zn<br /> | ||
| - | **[[1u43]] - EcMECPS + 2P-CDME<br /> | ||
| - | **[[1t0a]] - MECPS + farnesyl phosphate + Co + Zn - ''Shewanella oneidensis''<br /> | ||
| - | **[[2pmp]] - MECPS + CMP + Zn – ''Arabidopsis thaliana''<br /> | ||
| - | **[[4c8e]], [[4c8g]] - BcMECPS + CMP + Zn – ''Burkholderia cenocepacia''<br /> | ||
| - | **[[4c8i]] - BcMECPS + citrate + Zn <br /> | ||
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| - | *MECPS ternary complex | ||
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| - | **[[3iew]] - BpMECPS + CDP + CTP + Zn<br /> | ||
| - | **[[1jy8]] – EcMECPS + MECP + CMP + Zn<br /> | ||
| - | **[[1knj]] - EcMECPS + MECP + CMP + Mn<br /> | ||
| - | **[[3mbm]] - BpMECPS + imidazo-thiazol derivative +cytosine + Zn<br /> | ||
| - | **[[3p10]] - BpMECPS + pyrimidine derivative + cytidine + Zn<br /> | ||
| - | **[[3t80]] - MECPS + pyrimidine derivative + cytidine + Zn – ''Salmonella enterica''<br /> | ||
| - | **[[1yqn]] – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn<br /> | ||
| - | **[[2amt]] - EcMECPS + CMP derivative + geranyl diphosphate + Zn<br /> | ||
| - | **[[3elc]], [[3eor]], [[3ern]], [[3fba]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn<br /> | ||
| - | **[[3esj]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn<br /> | ||
| - | **[[2gzl]] - EcMECPS + inhibitor + geranyl diphosphate + Zn<br /> | ||
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| - | *MECPS quaternary complex | ||
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| - | **[[3p0z]], [[3qhd]] - BpMECPS + imidazo derivative + pyrimidine derivative + cytidine + Zn<br /> | ||
| - | **[[1h48]] - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Richard SB, Ferrer JL, Bowman ME, Lillo AM, Tetzlaff CN, Cane DE, Noel JP. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J Biol Chem. 2002 Mar 8;277(10):8667-72. Epub 2002 Jan 10. PMID:11786530 doi:http://dx.doi.org/10.1074/jbc.C100739200
- ↑ Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY. Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):23-31. Epub 2002, Dec 19. PMID:12499535
- ↑ Kemp LE, Bond CS, Hunter WN. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6591-6. Epub 2002 May 7. PMID:11997478 doi:10.1073/pnas.102679799
