6t84
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA== | |
| + | <StructureSection load='6t84' size='340' side='right'caption='[[6t84]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6t84]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T84 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t84 OCA], [http://pdbe.org/6t84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t84 RCSB], [http://www.ebi.ac.uk/pdbsum/6t84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t84 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Trehalose monomycolate (TMM) represents an essential element of the mycobacterial envelope. While synthesized in the cytoplasm, TMM is transported across the inner membrane by MmpL3 but, little is known regarding the MmpL3 partners involved in this process. Recently, the TMM transport factor A (TtfA) was found to form a complex with MmpL3 and to participate in TMM transport, although its biological role remains to be established. Herein, we report the crystal structure of the Mycobacterium smegmatis TtfA core domain. The phylogenetic distribution of TtfA homologues in non-mycolate containing bacteria suggests that TtfA may exert additional functions. | ||
| - | + | The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold.,Ung KL, Alsarraf HMAB, Kremer L, Blaise M Proteins. 2019 Dec 12. doi: 10.1002/prot.25863. PMID:31833106<ref>PMID:31833106</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6t84" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blaise, M]] | ||
| + | [[Category: Lipid transport]] | ||
| + | [[Category: Mmpl3 accessory protein]] | ||
| + | [[Category: Trehalose monomycolate]] | ||
Revision as of 09:19, 25 December 2019
crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA
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