6t8h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi== | |
| - | + | <StructureSection load='6t8h' size='340' side='right'caption='[[6t8h]], [[Resolution|resolution]] 3.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6t8h]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t8h OCA], [http://pdbe.org/6t8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t8h RCSB], [http://www.ebi.ac.uk/pdbsum/6t8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t8h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PCNA_PYRAB PCNA_PYRAB]] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317]<ref>PMID:22431731</ref> [[http://www.uniprot.org/uniprot/DP2S_PYRAB DP2S_PYRAB]] Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DNA-directed DNA polymerase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Beaufet, I Hugonneau]] | ||
| + | [[Category: Carroni, M]] | ||
| + | [[Category: Delarue, M]] | ||
| + | [[Category: England, P]] | ||
| + | [[Category: Lindhal, E]] | ||
| + | [[Category: Madru, C]] | ||
| + | [[Category: Pehau-Arnaudet, G]] | ||
| + | [[Category: Raia, P]] | ||
| + | [[Category: Sauguet, L]] | ||
| + | [[Category: Dp1]] | ||
| + | [[Category: Dp2]] | ||
| + | [[Category: Pcna]] | ||
| + | [[Category: Pip-box]] | ||
| + | [[Category: Pold]] | ||
| + | [[Category: Replication]] | ||
Revision as of 06:53, 4 March 2020
Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi
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Categories: DNA-directed DNA polymerase | Large Structures | Beaufet, I Hugonneau | Carroni, M | Delarue, M | England, P | Lindhal, E | Madru, C | Pehau-Arnaudet, G | Raia, P | Sauguet, L | Dp1 | Dp2 | Pcna | Pip-box | Pold | Replication
